1980年至1985年间马提尼克岛、瓜德罗普岛、新喀里多尼亚、塔希提岛、塞内加尔及巴黎麻风分枝杆菌对氨苯砜的原发性和继发性耐药情况。

Primary and secondary dapsone resistance of M. leprae in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris between 1980 and 1985.

作者信息

Guelpa-Lauras C C, Cartel J L, Constant-Desportes M, Millan J, Bobin P, Guidi C, Brucker G, Flageul B, Guillaume J C, Pichet C

机构信息

Département de Bacteriologie-Virologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

出版信息

Int J Lepr Other Mycobact Dis. 1987 Dec;55(4):672-9.

PMID:3323369

Abstract

Primary and secondary dapsone resistance were studied among lepromatous patients living in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris. Four hundred fifteen biopsies were taken from clinically active and bacteriologically positive (bacterial index greater than 2) patients in the 6-year period of 1980-1985. Among these, 280 biopsies that contained 5 x 10(4) acid-fast bacilli per ml with a morphological index of at least 0.10 were inoculated into the mouse foot pad, and 229 harbored infective Mycobacterium leprae. Among the 129 infective M. leprae isolated from new cases, 54% had some degree of dapsone resistance, a low degree being prominent in all cases. Among the 100 infective M. leprae isolated from relapsed cases, 79% had a high or an intermediate degree of dapsone resistance. The annual incidence of secondary dapsone resistance was estimated to be about 0.55% in Guadeloupe.

摘要

对生活在马提尼克岛、瓜德罗普岛、新喀里多尼亚、塔希提岛、塞内加尔和巴黎的瘤型麻风患者的氨苯砜原发性和继发性耐药情况进行了研究。在1980年至1985年的6年期间，从临床症状活跃且细菌学检查呈阳性（细菌指数大于2）的患者身上采集了415份活检样本。其中，将每毫升含有5×10⁴条抗酸杆菌且形态学指数至少为0.10的280份活检样本接种到小鼠足垫中，有229份样本含有感染性麻风分枝杆菌。在从新发病例中分离出的129株感染性麻风分枝杆菌中，54%有一定程度的氨苯砜耐药性，所有病例中低度耐药较为突出。在从复发病例中分离出的100株感染性麻风分枝杆菌中，79%有高度或中度氨苯砜耐药性。据估计，瓜德罗普岛继发性氨苯砜耐药的年发病率约为0.55%。