Shepard C C, Rees R J, Levy L, Pattyn S R, Baohong J, Dela Cruz E C
Int J Lepr Other Mycobact Dis. 1986 Mar;54(1):11-5.
Because of the recent spate of reports of primary resistance to dapsone among patients with lepromatous leprosy, largely to small concentrations of the drug, a survey was made of the results of dapsone-susceptibility testing of strains of Mycobacterium leprae isolated before 1977 among six laboratories which employed the mouse foot pad technique for this work prior to that time. Data have been found for strains that had been isolated from 73 patients, representing 19 countries and dependencies, with previously untreated lepromatous leprosy; all 73 strains were inhibited from multiplication by dapsone administered to mice in a concentration of 0.0001 g per 100 g mouse diet. These data suggest that the properties of M. leprae isolated from previously untreated patients with respect to susceptibility to dapsone have changed since the years preceding 1977.
由于近期大量报告显示，瘤型麻风患者中出现对氨苯砜的原发性耐药，主要是对低浓度药物耐药，因此对1977年以前六个实验室采用小鼠足垫技术分离的麻风分枝杆菌菌株的氨苯砜药敏试验结果进行了调查。已获得从73例患者分离出的菌株的数据，这些患者代表19个国家和属地，患有未经治疗的瘤型麻风；所有73株菌株在给予小鼠每100克小鼠饲料含0.0001克氨苯砜的情况下，其繁殖均受到抑制。这些数据表明，自1977年前几年以来，从未经治疗的患者中分离出的麻风分枝杆菌对氨苯砜的敏感性特性发生了变化。
