Department of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Molecules. 2020 Nov 20;25(22):5454. doi: 10.3390/molecules25225454.
The aim of this study was to assess the photostability of quercetin in the presence of anionic and nonionic polymeric gels with varied compositions of an added component-glycerol. The samples were irradiated continuously at constant temperature. The stability of quercetin in solution and incorporated into the gels was evaluated by an UV-Vis spectrophotometer. FTIR spectroscopy (Fourier-transform infrared spectroscopy) was used to detect the changes in the structure of quercetin depending on the polymer used in the gel, and on the exposure time. Photostabilization is an important aspect of quality assurance in photosensitive compounds. The decomposition rate of quercetin in the ionic preparation of polyacrylic acid (PAA) with glycerol was 1.952·10 min, whereas the absence of glycerol resulted in a decay rate of 5.032·10 min. The formulation containing non-ionic methylcellulose resulted in a decomposition rate of quercetin in the range of 1.679·10 min. The decay rate of quercetin under light influence depended on the composition of the gel. It was found that the cross-linked PAA stabilized quercetin and the addition of glycerol accelerated the photodegradation.
本研究旨在评估槲皮素在含有不同添加成分甘油的阴离子和非离子聚合物凝胶中的光稳定性。样品在恒定温度下连续照射。通过紫外可见分光光度计评估了溶液中和掺入凝胶中的槲皮素的稳定性。傅里叶变换红外光谱（傅里叶变换红外光谱）用于检测根据凝胶中使用的聚合物以及暴露时间，槲皮素结构的变化。光稳定性是光敏感化合物质量保证的一个重要方面。在含甘油的聚丙烯酸（PAA）离子制剂中，槲皮素的分解速率为 1.952·10 min，而不含甘油的分解速率为 5.032·10 min。含有非离子甲基纤维素的配方导致槲皮素的分解速率在 1.679·10 min 的范围内。光影响下槲皮素的衰减速率取决于凝胶的组成。结果发现，交联的 PAA 稳定了槲皮素，并且甘油的添加加速了光降解。
