Department of Physical Chemistry and Biophysics, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Int J Mol Sci. 2021 Jul 12;22(14):7466. doi: 10.3390/ijms22147466.
The ongoing search for effective treatment of Acne vulgaris is concentrated, i.a., on natural peptides with antimicrobial properties. The aim of this work was the development of new amino acid derivatives with potential activity on dermal infections against selected microorganisms, including the facultative anaerobe . The peptides P1-P6 were synthesized via Fmoc solid phase peptide synthesis using Rink amide AM resin, analyzed by RP-HPLC-MS, FTIR, DPPH radical scavenging activity, and evaluated against and , both deposited and non-deposited in BC. Peptides P1-P6 presented a lack of cytotoxicity, antimicrobial activity, or antioxidative properties correlated with selected structural properties. P2 and P4-P6 sorption in BC resulted in variable data, i.a., confirming the prospective topical application of these peptides in a BC carrier.
目前，人们致力于寻找治疗寻常痤疮的有效方法，特别关注具有抗菌特性的天然肽。本工作的目的是开发具有抗皮肤感染活性的新型氨基酸衍生物，针对包括兼性厌氧菌在内的选定微生物。通过使用 Fmoc 固相肽合成法，在 Rink 酰胺 AM 树脂上合成肽 P1-P6，通过 RP-HPLC-MS、FTIR、DPPH 自由基清除活性进行分析，并针对 和 进行评估，两者均在 BC 中沉积和非沉积。肽 P1-P6 表现出缺乏细胞毒性、抗菌活性或抗氧化特性，这与所选结构特性相关。P2 和 P4-P6 在 BC 中的吸附产生了不同的数据，例如，证实了这些肽在 BC 载体中的潜在局部应用。
