炎症性肠病门诊患者睡眠质量差的患病率及相关因素。
Prevalence and factors associated with poor sleep quality in inflammatory bowel disease outpatients.
机构信息
Medicina, Dermatología y Toxicología, Universidad de Valladolid.
Aparato Digestivo, Hospital Clínico Universitario de Valladolid.
出版信息
Rev Esp Enferm Dig. 2021 Jul;113(7):512-518. doi: 10.17235/reed.2020.7202/2020.
INTRODUCTION
sleep disorders are common in the general population and have obvious repercussions on quality of life. Poor sleep quality is associated to inflammatory activity and fatigue in inflammatory bowel disease (IBD) patients. This study aimed to analyze the prevalence of poor sleep quality and the factors associated with it, in IBD outpatients.
METHODS
an observational and prospective study was performed in which epidemiological, clinical and laboratory data were collected from clinical records and patients who consecutively attended an outpatient clinic. Pittsburgh Sleep Quality index (PSQI), Hospital Anxiety and Depression Scale (HADS) and International Physical Activity Questionnaire (IPAQ) were used to measure sleep quality, anxiety, depression and physical activity, respectively. Treatment optimizations, hospital admissions or surgery were prospectively verified three months after the baseline visit.
RESULTS
one hundred and two patients were included and 54.9 % had poor sleep quality (PSQI score > 5). No association was found between poor sleep quality and IBD-related variables such as type of disease, ulcerative colitis (UC) extent, Crohn's disease (CD) location or behavior, time from diagnosis, treatment, prior admissions or surgery and laboratory values. Rotating night shift job (OR 6.116, 95 % CI: 1.312-28.514), HAD score for depression (OR 1.125, 95 % CI: 1.062-1.490) and frequency (days per week) of vigorous physical activity (OR 0.783, 95 % CI: 0.619-0.991) were independent predictors of poor sleep quality. A Pittsburgh questionnaire score higher than 5 was not significantly associated to treatment optimization in the total patient cohort (15.2 % vs 18.2 %, p = 0.451), in UC patients (18.2 % vs 10.7 %, p = 0.362) or CD patients (12.5 % vs 25.9 %, p = 0.198).
CONCLUSIONS
poor sleep quality is present in more than half of IBD patients. Aspects not directly related to IBD are associated to poor sleep quality.
简介
睡眠障碍在普通人群中很常见，对生活质量有明显影响。在炎症性肠病（IBD）患者中，睡眠质量差与炎症活动和疲劳有关。本研究旨在分析 IBD 门诊患者睡眠质量差的患病率及相关因素。
方法
进行了一项观察性前瞻性研究，从临床记录和连续就诊的患者中收集流行病学、临床和实验室数据。使用匹兹堡睡眠质量指数（PSQI）、医院焦虑抑郁量表（HADS）和国际体力活动问卷（IPAQ）分别测量睡眠质量、焦虑、抑郁和体力活动。治疗优化、住院或手术在基线就诊后三个月内进行前瞻性验证。
结果
共纳入 102 例患者，其中 54.9%存在睡眠质量差（PSQI 评分>5）。睡眠质量差与 IBD 相关变量无相关性，如疾病类型、溃疡性结肠炎（UC）程度、克罗恩病（CD）部位或行为、诊断后时间、治疗、既往住院或手术及实验室值。轮班夜班工作（OR 6.116，95%CI：1.312-28.514）、抑郁 HADS 评分（OR 1.125，95%CI：1.062-1.490）和剧烈体力活动（OR 0.783，95%CI：0.619-0.991）的频率（每周天数）是睡眠质量差的独立预测因素。在总患者队列中，匹兹堡问卷评分>5 与治疗优化无显著相关性（15.2%与 18.2%，p=0.451），在 UC 患者中（18.2%与 10.7%，p=0.362）或 CD 患者中（12.5%与 25.9%，p=0.198）。
结论
超过一半的 IBD 患者存在睡眠质量差。与 IBD 不直接相关的方面与睡眠质量差有关。
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