Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, 81 Meishan Road, Hefei, Anhui, China.
Department of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, China.
Int Immunopharmacol. 2021 Jan;90:107127. doi: 10.1016/j.intimp.2020.107127. Epub 2020 Nov 21.
The Ets transcription factor family exerts crucial role in cell proliferation, apoptosis, differentiation and migration. Friend leukemia integration 1 (Fli1), a member of the Ets family, is expressed in fibroblasts, endothelial cells and immune cells. Fli1 gene is participated in the development, proliferation, activation, migration and other processes of immune cells. Fli1 can also affect the function of immune cells by regulating cytokines and chemokines. Emerging evidence has shown that Fli1 is implicated in the etiology of several autoimmune diseases, including systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). In this review, we mainly discuss the current evidence for the role of Fli1 in these diseases.
Ets 转录因子家族在细胞增殖、凋亡、分化和迁移中发挥着关键作用。Friend 白血病整合蛋白 1（Fli1）是 Ets 家族的一员，在成纤维细胞、内皮细胞和免疫细胞中表达。Fli1 基因参与免疫细胞的发育、增殖、激活、迁移等过程。Fli1 还可以通过调节细胞因子和趋化因子来影响免疫细胞的功能。新出现的证据表明，Fli1 与几种自身免疫性疾病的发病机制有关，包括系统性硬化症（SSc）和系统性红斑狼疮（SLE）。在这篇综述中，我们主要讨论了 Fli1 在这些疾病中的作用的现有证据。
