Sun Ruirui, Zhou Jie, Qu Yuzhu, Zhou Jun, Xu Guixing, Cheng Shirui
The Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu.
The Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, China.
Medicine (Baltimore). 2020 Nov 25;99(48):e23292. doi: 10.1097/MD.0000000000023292.
Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders (FGIDs) and significantly influences patients' quality of life. Many studies have found that patients with FD show significant functional abnormalities in multiple brain regions. However, these functional cerebral abnormalities are not fully consistent. This protocol aims to qualitatively and quantitatively assess and synthesize the functional cerebral abnormalities found in FD.
A systematic search will be conducted in 4 electronic databases (Medline, Web of Science, EMBASE, and the Cochrane Library) from inception to June 30, 2019, with the language restricted to English. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Quality assessment will be performed with a custom 11-point checklist. The functional changes in brain regions and the correlations between these altered brain regions and clinical variables in patients with FD will be evaluated through qualitative review. If data are available, an Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) will be used to synthesize the brain functional alterations and clinical variables in patients with FD.
This review and meta-analysis will qualitatively and quantitatively assess and synthesize functional cerebral abnormalities consistently found in FD.
This may assist in mapping functional brain abnormalities to characterize imaging-based neural markers of FD and improve our knowledge of the pathogenesis of FD.
CRD42019134983 (https://www.crd.york.ac.uk/prospero/).
功能性消化不良（FD）是最常见的功能性胃肠疾病（FGID）之一，对患者的生活质量有显著影响。许多研究发现，FD患者在多个脑区存在明显的功能异常。然而，这些脑功能异常并不完全一致。本方案旨在定性和定量评估并综合FD中发现的脑功能异常。
将在4个电子数据库（Medline、Web of Science、EMBASE和Cochrane图书馆）中进行系统检索，检索时间从建库至2019年6月30日，语言限制为英语。研究选择将遵循系统评价和Meta分析的首选报告项目（PRISMA）指南。将使用自定义的11分清单进行质量评估。通过定性综述评估FD患者脑区的功能变化以及这些改变的脑区与临床变量之间的相关性。如果有可用数据，将使用符号差异映射的各向异性效应量版本（AES-SDM）来综合FD患者的脑功能改变和临床变量。
本综述和Meta分析将定性和定量评估并综合FD中一致发现的脑功能异常。
这可能有助于绘制脑功能异常图谱，以表征基于影像学的FD神经标志物，并增进我们对FD发病机制的了解。
PROSPERO注册号：CRD42019134983（https://www.crd.york.ac.uk/prospero/）。
