Zhang Xueping, Chen Lei, Zhang Tao, Gabo Ryu, Wang Qianying, Zhong Zhuotai, Yao Mengxi, Wei Wei, Su Xiaolan
Department of Gastroenterology, Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Microbiol. 2024 Aug 6;15:1409280. doi: 10.3389/fmicb.2024.1409280. eCollection 2024.
Functional dyspepsia (FD) is a common gastrointestinal disorder associated with brain-gut interaction disturbances. In recent years, accumulating evidence points to the duodenum as a key integrator in dyspepsia symptom generation. Investigations into the pathological changes in the duodenum of FD patients have begun to focus on the role of duodenal microbiota dysbiosis. This review summarizes duodenal microbiota changes in FD patients and explores their relationship with gut-brain interaction dysregulation.
Ten databases, including PubMed, MEDLINE, and the Cochrane Library, were searched from inception to 10th October 2023 for clinical interventional and observational studies comparing the duodenal microbiota of FD patients with controls. We extracted and qualitatively summarized the alpha diversity, beta diversity, microbiota composition, and dysbiosis-related factors.
A total of nine studies, consisting of 391 FD patients and 132 non-FD controls, were included. The findings reveal that the alpha diversity of the duodenal microbiota in FD patients does not exhibit a significant difference compared to non-FD controls, although an upward trend is observed. Furthermore, alterations in the duodenal microbiota of FD patients are associated with the symptom burden, which, in turn, impacts their quality of life. In FD patients, a considerable number of duodenal microbiota demonstrate a marked ascending trend in relative abundance, including taxa such as the phylum , the genera , , , , and . A more pronounced declining trend is observed in the populations of the genera , , , , , and within FD patients. A negative correlation in the relative abundance changes between and is identified, which correlates with the severity of symptom burden in FD patients. Moreover, the alterations in specific microbial communities in FD patients and their potential interactions with the gut-brain axis merit significant attention.
Microbial dysbiosis in FD patients is linked to the onset and exacerbation of symptoms and is related to the disorder of gut-brain interaction. Larger-scale, higher-quality studies, along with comprehensive meta-omics research, are essential to further elucidate the characteristics of the duodenal microbiota in FD patients and its role in FD pathogenesis.: CRD42023470279, URL: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023470279.
功能性消化不良（FD）是一种常见的胃肠道疾病，与脑-肠相互作用紊乱有关。近年来，越来越多的证据表明十二指肠是消化不良症状产生的关键整合部位。对FD患者十二指肠病理变化的研究已开始关注十二指肠微生物群失调的作用。本综述总结了FD患者十二指肠微生物群的变化，并探讨了它们与肠-脑相互作用失调的关系。
检索了包括PubMed、MEDLINE和Cochrane图书馆在内的10个数据库，从建库至2023年10月10日，查找比较FD患者与对照组十二指肠微生物群的临床干预和观察性研究。我们提取并定性总结了α多样性、β多样性、微生物群组成和与失调相关的因素。
共纳入9项研究，包括391例FD患者和132例非FD对照。研究结果表明，FD患者十二指肠微生物群的α多样性与非FD对照相比虽呈上升趋势，但无显著差异。此外，FD患者十二指肠微生物群的改变与症状负担相关，进而影响其生活质量。在FD患者中，相当数量的十二指肠微生物群相对丰度呈现明显上升趋势，包括门、属、、、、和等分类群。在FD患者中，属、、、、、和种群的下降趋势更为明显。发现和之间相对丰度变化呈负相关，并与FD患者症状负担的严重程度相关。此外，FD患者特定微生物群落的改变及其与肠-脑轴的潜在相互作用值得高度关注。
FD患者微生物群失调与症状的发生和加重有关，并与肠-脑相互作用紊乱有关。开展更大规模、更高质量的研究以及全面的多组学研究，对于进一步阐明FD患者十二指肠微生物群的特征及其在FD发病机制中的作用至关重要。：CRD42023470279，网址：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023470279 。
