Aday Ulaş, Tatlı Faruk, Akpulat Faik V, İnan Mazlum, Kafadar Mehmet T, Bilge Hüseyin, Başol Ömer, Oğuz Abdullah
Department of Gastrointestinal Surgery, Dicle University School of Medicine, Diyarbakır, Turkey.
Department of General Surgery, Dicle University School of Medicine, Diyarbakır, Turkey.
Contemp Oncol (Pozn). 2020;24(3):145-149. doi: 10.5114/wo.2020.100219. Epub 2020 Oct 30.
To investigate the prognostic role of lactate dehydrogenase-to-albumin ratio (LAR) in gastric cancer patients undergoing curative resection.
A retrospective study was conducted including resectable gastric cancer patients. According to the time-dependent receiver operating characteristics (ROC) analysis, the optimal threshold for pretreatment LAR was 5.5. The Kaplan-Meier method, Cox regression univariate and multivariate analyses were used to analyze the prognostic factors for disease-free survival and overall survival (OS).
The study cohort consisted of 81 patients, mean age was 60.2 ±13.8 (range, 29-87) years and 55 (67.9%) were male. The median OS time was 34.8 and 45 months in patients with LAR ≥ 5.5 ( = 50) and LAR < 5.5 ( = 31), respectively. Kaplan-Meier curves showed that with the increase in LAR there was reduced survival, but it was not statistically significant ( = 0.278). Multivariate analyses revealed that the positive lymph node ratio above 20% was an independent predictor in resectable gastric cancer patients (OR = 6.281, 95% CI: 1.135-34.767, = 0.035).
With the increase in LAR survival in gastric cancer decreased, but it was not statistically significant. Studies involving a large patient series are needed.
探讨乳酸脱氢酶与白蛋白比值（LAR）在接受根治性切除的胃癌患者中的预后作用。
进行一项回顾性研究，纳入可切除胃癌患者。根据时间依赖性受试者工作特征（ROC）分析，预处理LAR的最佳阈值为5.5。采用Kaplan-Meier法、Cox回归单因素和多因素分析来分析无病生存期和总生存期（OS）的预后因素。
研究队列由81例患者组成，平均年龄为60.2±13.8（范围29-87）岁，55例（67.9%）为男性。LAR≥5.5（n=50）和LAR<5.5（n=31）的患者中位OS时间分别为34.8个月和45个月。Kaplan-Meier曲线显示，随着LAR升高，生存率降低，但差异无统计学意义（P=0.278）。多因素分析显示，阳性淋巴结比例高于20%是可切除胃癌患者的独立预测因素（OR=6.281，95%CI：1.135-34.767，P=0.035）。
随着LAR升高，胃癌患者生存率降低，但差异无统计学意义。需要开展涉及大量患者系列的研究。
