Wang Zi-Xian, Yang Lu-Ping, Qiu Miao-Zhen, Wang Zhi-Qiang, Zhou Yi-Xin, Wang Feng, Zhang Dong-Sheng, Wang Feng-Hua, Li Yu-Hong, Xu Rui-Hua
Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Faculty of Medical Sciences, Sun Yat-sen University, Guangzhou, China.
Oncotarget. 2016 Jun 28;7(26):39945-39956. doi: 10.18632/oncotarget.9459.
The present study aimed to evaluate the prognostic significance of preoperative serum lactate dehydrogenase (SLDH) levels for resected gastric cancer and construct prognostic nomograms for risk prediction. The study cohort consisted of 619 patients with D2-resected gastric cancer. The relationship of SLDH levels with clinicopathological features and clinical outcomes was evaluated. Prognostic nomograms were created using identified prognosticators to predict 3-year overall survival (OS) and 3-year disease-free survival (DFS), and bootstrap validation was performed. High SLDH levels were correlated with old age but not depth of invasion or lymph node metastasis. When assessed as a continuous variable, high SLDH levels were independently associated with poor OS and DFS. Internal validation of the developed nomograms revealed good predictive accuracy (bootstrap-corrected concordance indices: 0.77 and 0.75, respectively for prediction of OS and DFS). The preoperative SLDH levels, an identified unfavorable prognosticator, were incorporated into nomograms along with other clinicopathological features to refine the prediction of clinical outcomes for patients with D2-resected gastric cancer.
本研究旨在评估术前血清乳酸脱氢酶（SLDH）水平对接受手术切除的胃癌患者的预后意义，并构建用于风险预测的预后列线图。研究队列包括619例接受D2根治性切除术的胃癌患者。评估了SLDH水平与临床病理特征及临床结局之间的关系。使用确定的预后因素创建预后列线图，以预测3年总生存期（OS）和3年无病生存期（DFS），并进行自助法验证。高SLDH水平与老年相关，但与浸润深度或淋巴结转移无关。当作为连续变量评估时，高SLDH水平与较差的OS和DFS独立相关。所开发列线图的内部验证显示出良好的预测准确性（自助法校正一致性指数：预测OS和DFS分别为0.77和0.75）。术前SLDH水平是一个已确定的不良预后因素，与其他临床病理特征一起纳入列线图，以优化对接受D2根治性切除术的胃癌患者临床结局的预测。
