Majewski Marek, Mertowska Paulina, Mertowski Sebastian, Smolak Konrad, Grywalska Ewelina, Torres Kamil
2nd Department of General, Gastrointestinal Surgery and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, 20-081 Lublin, Poland.
Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
Cancers (Basel). 2022 Aug 8;14(15):3832. doi: 10.3390/cancers14153832.
Gastric cancer remains one of the most commonly diagnosed cancers in the world, with a relatively high mortality rate. Due to the heterogeneous course of the disease, its diagnosis and treatment are limited and difficult, and it is associated with a reduced prognosis for patients. That is why it is so important to understand the mechanisms underlying the development and progression of this cancer, with particular emphasis on the role of risk factors. According to the literature data, risk factors include: changes in the composition of the stomach and intestinal microbiota (microbiological dysbiosis and the participation of ), improper diet, environmental and genetic factors, and disorders of the body's immune homeostasis. Therefore, the aim of this review is to systematize the knowledge on the influence of human microbiota dysbiosis on the development and progression of gastric cancer, with particular emphasis on the role of the immune system in this process.
胃癌仍然是世界上最常被诊断出的癌症之一，死亡率相对较高。由于该疾病病程的异质性，其诊断和治疗受到限制且困难，并且与患者预后不良相关。这就是为什么了解这种癌症发生和发展的潜在机制如此重要，尤其要强调风险因素的作用。根据文献数据，风险因素包括：胃和肠道微生物群组成的变化（微生物失调及相关参与情况）、不当饮食、环境和遗传因素以及机体免疫稳态紊乱。因此，本综述的目的是系统整理关于人类微生物群失调对胃癌发生和发展影响的知识，尤其强调免疫系统在此过程中的作用。
