通过血药浓度分析评估直接血液灌流清除苯巴比妥的疗效。
Efficacy of direct hemoperfusion for the removal of phenobarbital through blood concentration analysis.
作者信息
Mizushima Shohei, Hirose Yousuke, Yuzawa Hiroko, Kimura Tomonori, Oguchi Moe, Morito Tomohiro, Sadahiro Tomohito
机构信息
Department of Emergency and Critical Care Medicine Tokyo Women's Medical University Yachiyo Medical Center Chiba Japan.
出版信息
Acute Med Surg. 2020 Nov 17;7(1):e601. doi: 10.1002/ams2.601. eCollection 2020 Jan-Dec.
AIM
Phenobarbital overdose can cause coma and even death. The consciousness disturbance is often prolonged due to its long half-life. In this study, we investigated the efficacy of direct hemoperfusion (DHP) for the removal of phenobarbital by measuring the blood levels of phenobarbital.
METHODS
Study subjects included five patients with phenobarbital poisoning who were transferred to our hospital. Direct hemoperfusion was carried out in three of the five patients (six times in total), and the elimination rate was calculated by measuring the blood levels before and after DHP. Furthermore, the disappearance rate of phenobarbital without DHP was calculated in all five patients (seven times in total) for comparison with the elimination rate.
RESULTS
The elimination rate of phenobarbital with DHP was significantly higher than the disappearance rate without DHP．.
CONCLUSION
This study suggests that early introduction of DHP should be considered as a treatment option for phenobarbital poisoning.
目的
苯巴比妥过量可导致昏迷甚至死亡。由于其半衰期长，意识障碍往往会持续很长时间。在本研究中，我们通过测量苯巴比妥的血药浓度来研究直接血液灌流（DHP）清除苯巴比妥的疗效。
方法
研究对象包括五名转诊至我院的苯巴比妥中毒患者。五名患者中的三名接受了直接血液灌流（共六次），通过测量血液灌流前后的血药浓度来计算清除率。此外，计算了所有五名患者（共七次）未进行血液灌流时苯巴比妥的消失率，以便与清除率进行比较。
结果
进行血液灌流时苯巴比妥的清除率显著高于未进行血液灌流时的消失率。
结论
本研究表明，对于苯巴比妥中毒，应考虑尽早采用直接血液灌流作为一种治疗选择。
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