Lieb Bernhard, Schmitt Patrick
Institute of Molecular Physiology (imP), Johannes Gutenberg-University (JGU), Mainz, Germany.
BMJ Nutr Prev Health. 2020 Apr 30;3(1):31-39. doi: 10.1136/bmjnph-2019-000042. eCollection 2020.
To assess whether the symptoms of veisalgia can be reduced by intense water supply and the intake of antioxidative supplements and plant extracts.
We performed the world's largest randomised double-blind placebo-controlled intervention study (214 participants) on the efficacy of a food for special medical purposes (FSMP) against veisalgia symptoms. We analysed the effectiveness of: (1) an FSMP, including distinct plant extracts, vitamins and minerals, and additional (antioxidative) compounds; (2) a dietary supplement only comprising vitamins and minerals and additional (antioxidative) compounds; and (3) a placebo containing only glucose. The study followed the CONSORT (Consolidated Standards of Reporting Trials) guidelines and trial registration was not necessary.
Our study showed no statistically significant relationship between the variation of body water content and alcohol consumption. Contrary to common belief, the results showed that intervention with a supplement containing vitamins and minerals and additional antioxidative compounds did not lead to a statistically significant improvement in hangover symptoms. Additionally, our results confirmed a high individual variability in developing hangover symptoms depending on the amount of alcohol. Thus, standardisation of the amount of alcohol consumed in hangover studies does not necessarily contribute to the validity of the results. Finally, this study found a number of positive effects on certain hangover symptoms as a result of the FSMP, which were most likely due to the plant extracts contained within the food.
This study significantly supports the finding that haemostasis of electrolytes and minerals caused by alcohol consumption might be negligible and that no significant dehydration due to alcohol consumption seems to occur. Additionally, only the FSMP provides evidence for a significant efficiency in the reduction of hangover symptoms such as headache and nausea following moderate and non-excessive alcohol consumption.
评估大量饮水以及摄入抗氧化补充剂和植物提取物是否能减轻宿醉症状。
我们针对一种特殊医学用途食品（FSMP）缓解宿醉症状的功效开展了全球最大规模的随机双盲安慰剂对照干预研究（214名参与者）。我们分析了以下各项的有效性：（1）一种FSMP，包括不同的植物提取物、维生素和矿物质以及其他（抗氧化）化合物；（2）一种仅包含维生素和矿物质以及其他（抗氧化）化合物的膳食补充剂；（3）一种仅含葡萄糖的安慰剂。该研究遵循CONSORT（试验报告统一标准）指南，无需进行试验注册。
我们的研究表明，身体水分含量变化与酒精摄入量之间无统计学显著关系。与普遍看法相反，结果显示，使用含有维生素和矿物质以及其他抗氧化化合物的补充剂进行干预，并未使宿醉症状得到统计学上的显著改善。此外，我们的结果证实，取决于饮酒量，宿醉症状的出现存在很大的个体差异。因此，在宿醉研究中对饮酒量进行标准化并不一定有助于提高结果的有效性。最后，本研究发现FSMP对某些宿醉症状有一些积极影响，这很可能归因于该食品中所含的植物提取物。
本研究有力支持了以下发现：饮酒引起的电解质和矿物质平衡失调可能微不足道，且饮酒似乎不会导致明显脱水。此外，只有FSMP为适度且不过量饮酒后减轻头痛和恶心等宿醉症状的显著功效提供了证据。
