Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University, Kawasaki, Japan.
Laboratory for Neural Circuit Systems, Institute of Neuroscience, Tokushima Bunri University, Sanuki, Japan.
Bioessays. 2021 Mar;43(3):e2000084. doi: 10.1002/bies.202000084. Epub 2020 Nov 25.
In several experimental conditions, neuronal excitation at the perirhinal cortex (PC) does not propagate to the entorhinal cortex (EC) due to a "wall" of inhibition, which may help to create functional coupling and un-coupling of the PC and EC in the medial temporal lobe. However, little is known regarding the coupling control process. Herein, we propose that the deep layer of area 35 in the PC plays a pivotal role in opening the gate for coupling, thus allowing the activity in the PC to propagate to the EC. Using voltage-sensitive dye imaging for the brain slices of rodents, we show that a slowly inactivating potassium conductance in this area is essential to induce excitation overtaking the inhibitory control. This coupling between the distinct neural circuits persists for at least 1 h. We elucidate further implications of this network-level plastic behavior and its mechanism.
在几种实验条件下，由于存在“抑制墙”，故毗邻皮质（PC）的神经元兴奋不会传播到内嗅皮质（EC），该抑制墙有助于在颞叶内创建 PC 和 EC 的功能偶联和去偶联。然而，对于偶联控制过程知之甚少。在此，我们提出 PC 中的 35 区深层在打开偶联之门方面起着关键作用，从而使 PC 的活动传播到 EC。通过对啮齿动物脑片的电压敏感染料成像，我们表明该区域中缓慢失活的钾电导对于诱导兴奋克服抑制控制是必需的。这种独特的神经回路之间的耦合至少持续 1 小时。我们进一步阐明了这种网络水平的可塑性行为及其机制的含义。
