Tominaga Takashi, Kajiwara Riichi, Tominaga Yoko
Institute of Neuroscience, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan.
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan.
Biophys Physicobiol. 2023 Mar 11;20(1):e200015. doi: 10.2142/biophysico.bppb-v20.0015. eCollection 2023.
Plasticity is the key feature of our brain function. Specifically, plasticity of hippocampal synapses is critical for learning and memory. The functional properties of the neuronal circuit change as a result of synaptic plasticity. This review summarizes the use of voltage-sensitive dyes (VSDs) to examine neuronal circuit plasticity. We will discuss the significance of plastic changes in circuit function as well as the technical issue of using VSDs. Further, we will discuss the neural circuit level plasticity of the hippocampus caused by long-term potentiation and the entorhinal-perirhinal connection. This review article is an extended version of the Japanese article, Membrane Potential Imaging with Voltage-sensitive Dye (VSD) for Long-term Recording, published in SEIBUTSU BUTSURI Vol. 61, p. 404-408 (2021).
可塑性是我们大脑功能的关键特征。具体而言，海马体突触的可塑性对学习和记忆至关重要。神经元回路的功能特性会因突触可塑性而发生改变。本综述总结了使用电压敏感染料（VSDs）来检测神经元回路可塑性的情况。我们将讨论回路功能中可塑性变化的意义以及使用VSDs的技术问题。此外，我们还将讨论由长时程增强和内嗅-嗅周连接引起的海马体神经回路水平的可塑性。这篇综述文章是发表于《生物物理》第61卷，第404 - 408页（2021年）的日文文章《用于长期记录的电压敏感染料（VSD）膜电位成像》的扩展版本。
