Department of Psychology, National University of Singapore, Singapore.
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
Addict Biol. 2021 May;26(3):e12976. doi: 10.1111/adb.12976. Epub 2020 Nov 24.
Abnormal decision making can result in detrimental outcomes of clinical importance, and decision making is strongly linked to neural prediction error signalling. Activation likelihood estimation (ALE) meta-analyses were used to examine the neural correlates of prediction error signals of individuals taking different types of substances and healthy controls with contrast and conjunction analyses. Twenty-eight studies were included in the meta-analysis, representing 424 substance users' individuals and 834 healthy control individuals. Robust brain activity associated with prediction error signals in substance users was found for the bilateral striatum and insula. Healthy control subjects also activated bilateral striatum, midbrain, right insula and right medial-inferior frontal gyrus. Compared with healthy controls, substance users showed blunted activity in the bilateral putamen, right medial-inferior frontal gyrus and insula. The current meta-analysis of cross-sectional findings investigated neural prediction error signals in substance users. PE abnormalities in substance users might be related to poor decision making. In conclusion, the present study helps identify the pathophysiological underpinnings of maladaptive decision making in substance users.
异常的决策可能会导致具有临床重要性的不利后果，而决策与神经预测误差信号密切相关。本研究采用激活似然估计（ALE）元分析，通过对比和联合分析，研究了不同类型物质使用者和健康对照者的预测误差信号的神经相关性。该元分析纳入了 28 项研究，共涉及 424 名物质使用者个体和 834 名健康对照个体。研究结果发现，物质使用者的双侧纹状体和脑岛与预测误差信号相关的脑活动较为强烈。健康对照组的双侧纹状体、中脑、右侧脑岛和右侧额中下回也有激活。与健康对照组相比，物质使用者的双侧壳核、右侧额中下回和脑岛的活动减弱。本横断面研究的元分析调查了物质使用者的神经预测误差信号。物质使用者的 PE 异常可能与较差的决策能力有关。总之，本研究有助于确定物质使用者不良决策的病理生理基础。
