Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Commun Biol. 2024 Aug 14;7(1):988. doi: 10.1038/s42003-024-06638-z.
Social controllability, or the ability to exert control during social interactions, is crucial for optimal decision-making. Inability to do so might contribute to maladaptive behaviors such as smoking, which often takes place in social settings. Here, we examined social controllability in nicotine-dependent humans as they performed an fMRI task where they could influence the offers made by simulated partners. Computational modeling revealed that smokers under-estimated the influence of their actions and self-reported a reduced sense of control, compared to non-smokers. These findings were replicated in a large independent sample of participants recruited online. Neurally, smokers showed reduced tracking of forward projected choice values in the ventromedial prefrontal cortex, and impaired computation of social prediction errors in the midbrain. These results demonstrate that smokers were less accurate in estimating their personal influence when the social environment calls for control, providing a neurocomputational account for the social cognitive deficits in this population. Pre-registrations: OSF Registries|How interoceptive state interacts with value-based decision-making in addiction (fMRI study). OSF Registries|COVID-19: social cognition, mental health, and social distancing (online study).
社会可控制性，即在社交互动中施加控制的能力，对于做出最佳决策至关重要。无法做到这一点可能会导致适应不良的行为，例如吸烟，而吸烟通常发生在社交环境中。在这里，我们在进行 fMRI 任务时检查了依赖尼古丁的人类的社会可控制性，在该任务中，他们可以影响模拟伙伴提出的报价。计算模型表明，与不吸烟者相比，吸烟者低估了他们行为的影响，并自我报告控制感降低。在在线招募的大量独立参与者样本中复制了这些发现。从神经学上讲，吸烟者在腹内侧前额叶皮层中显示出对向前投射的选择值的跟踪减少，并且在中脑中对社会预测误差的计算受损。这些结果表明，当社交环境需要控制时，吸烟者在估计自己的个人影响力方面准确性降低，为该人群的社会认知缺陷提供了神经计算解释。预注册：OSF 注册|内感受状态如何与成瘾中的基于价值的决策相互作用（fMRI 研究）。OSF 注册|COVID-19：社会认知、心理健康和社交距离（在线研究）。
