The influence of nutrition on the systemic availability of drugs. Part II: Drug metabolism and renal excretion.

Plasma concentrations of an active compound vary between individuals and within a subject, even if the same drug dosage is used. These differences are related to variations of drug absorption from the gastrointestinal tract, of presystemic drug metabolism in the intestine or the liver, and of drug elimination from the systemic circulation, for instance by hepatic metabolism or renal excretion. All of these processes can be modified by nutrition. However it is necessary to emphasize the significance of the pharmaceutical formulation for variations of both drug absorption and elimination. The role of nutrition should receive adequate attention during therapeutic use of drugs as well as in drug disposition studies. Recent guidelines for the assessment of the systemic availability of drugs therefore do recommend nutrition to be controlled.