Walle T, Fagan T C, Walle U K, Oexmann M J, Conradi E C, Gaffney T E
Clin Pharmacol Ther. 1981 Dec;30(6):790-5. doi: 10.1038/clpt.1981.239.
The influence of a meal on the disposition and metabolism of oral propranolol was examined in six normal subjects. The meal induced a mean 53% increase in propranolol bioavailability (range 2% to 92%; P less than 0.01) without affecting time to maximum concentration, half-life, or the amount of unchanges drug in urine. There was no effect on the plasma concentrations of 4-hydroxypropranolol or four other metabolites. The increased bioavailability was linearly related to the protein content of the meal (r = 0.884, P less than 0.02) above a threshold content of about 7 gm.
在6名正常受试者中研究了进餐对口服普萘洛尔处置和代谢的影响。进餐使普萘洛尔的生物利用度平均增加53%（范围为2%至92%；P<0.01），而不影响达峰时间、半衰期或尿中未变化药物的量。对4-羟基普萘洛尔或其他四种代谢物的血浆浓度没有影响。生物利用度的增加与进餐的蛋白质含量呈线性相关（r = 0.884，P<0.02），阈值含量约为7克。
