Bottasso O, Poli H O, Morini J C
Departamento de Ciencias Fisiológicas, Facultad de Ciencias Médicas, UNR, Rosario, Argentina.
Med Cutan Ibero Lat Am. 1987;15(6):504-10.
The delayed type hypersensitivity (DTH) response to PPD, candidin and histoplasmin, and Mitsuda reaction (MR) in household contacts (HC) of multibacillary (HCM) and paucibacillary (HCP) leprosy patients, and non exposed controls was studied. Intradermal tests with 0.1 ml. of each antigen were performed and read after 48 hours. Late nodular reaction to ML (MR) was evaluated at the 21st day post-challenge. As we had formerly demonstrated, MR was depressed in HCM. Interestingly, this reaction was also depressed in HCP to a lesser magnitude. HCM had a lower DTH response to histoplasmin in relation to PPD and candidin when persons were simultaneously challenged with the three antigens. According to these results we conclude that: a), HCM have a depression in late lepromin reaction; b), in HCP the depression in MR is of a lower magnitude. We hypothesize that in healthy contacts of bacilliferous patients an active mechanism of immunosuppression to mycobacterial antigens may be produced. Alterations in the skin response to histoplasmin is discussed.
研究了多菌型（HCM）和少菌型（HCP）麻风患者的家庭接触者（HC）以及未接触过的对照者对结核菌素纯蛋白衍生物（PPD）、念珠菌素和组织胞浆菌素的迟发型超敏反应（DTH）以及麻风菌素反应（MR）。用0.1毫升每种抗原进行皮内试验，并在48小时后读取结果。在激发后第21天评估对麻风菌素（MR）的晚期结节反应。正如我们之前所证明的，HCM中的MR受到抑制。有趣的是，HCP中的这种反应也有较小程度的抑制。当同时用三种抗原对人员进行激发时，HCM对组织胞浆菌素的DTH反应相对于PPD和念珠菌素较低。根据这些结果我们得出结论：a），HCM的晚期麻风菌素反应受到抑制；b），HCP中MR的抑制程度较低。我们推测在带菌患者的健康接触者中可能产生了针对分枝杆菌抗原的主动免疫抑制机制。文中讨论了皮肤对组织胞浆菌素反应的改变。
