Goulart Maria JÚlia V C, Pisamiglio Daniela S, MÖller Gabriella B, Dani Caroline, Alves Fernanda D, Bock PatrÍcia M, Schneider ClÁudia D
Programa de Pós-Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245, 90050-170 Porto Alegre, RS, Brazil.
Curso de Nutrição, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245, 90050-170 Porto Alegre, RS, Brazil.
An Acad Bras Cienc. 2020 Nov 20;92(4):e20191551. doi: 10.1590/0001-3765202020191551. eCollection 2020.
Physiological levels of reactive oxygen species (ROS) are important for intracellular and extracellular redox regulation in signaling and defense processes. Strenuous exercise can also contribute to this imbalance, and the muscle fatigue, evidenced by impaired strength or power generation, can be caused by various reasons, including oxidative stress. Antioxidants can prevent the formation of ROS by intercepting free radicals. Twenty judo athletes were included in this randomized, double-blind clinical trial into grape juice and placebo groups, and they consumed grape juice or placebo daily for 14 days in a crossover model. The outcomes were analyzed before and after combat simulations. The upper limb strength was higher in the grape juice group than in the placebo (p [group] = 0.003). The lipid damage levels were 10% higher in the placebo group (p [interaction] = 0.048). During the pre-exercise, the placebo group showed 19% more DNA damage than the grape juice group. The superoxide dismutase activity was 80% lower in the grape juice group (p [interaction] < 0.001). The consumption of grape juice can improve parameters of oxidative stress by reducing the lipid and DNA damage.
活性氧（ROS）的生理水平对于信号传导和防御过程中的细胞内和细胞外氧化还原调节很重要。剧烈运动也会导致这种失衡，而以力量或能量产生受损为特征的肌肉疲劳可能由多种原因引起，包括氧化应激。抗氧化剂可以通过拦截自由基来防止ROS的形成。20名柔道运动员被纳入这项关于葡萄汁和安慰剂组的随机双盲临床试验，他们以交叉模型每天饮用葡萄汁或安慰剂，持续14天。在战斗模拟前后对结果进行分析。葡萄汁组的上肢力量高于安慰剂组（p[组间]=0.003）。安慰剂组的脂质损伤水平高10%（p[交互作用]=0.048）。在运动前，安慰剂组的DNA损伤比葡萄汁组多19%。葡萄汁组的超氧化物歧化酶活性低80%（p[交互作用]<0.001）。饮用葡萄汁可以通过减少脂质和DNA损伤来改善氧化应激参数。
