Grupo Infecciones y Salud en el Trópico, Universidad Nacional de Colombia, Bogotá, Colombia.
Grupo Medicina Comunitaria y Salud Colectiva, Universidad El Bosque, Bogotá, Colombia.
Cad Saude Publica. 2020 Nov 23;36(11):e00215319. doi: 10.1590/0102-311X00215319. eCollection 2020.
In 2015, the Zika virus was introduced in Colombia. The emergence of this arbovirus is a public health challenge for the country, considering the association between the infection and congenital disorders such as microcephaly. Thus, we estimated the burden of disease due to microcephaly associated with Zika in Colombia and its administrative subdivisions for the period 2015-2016. We conducted an exploratory ecological study, using as unit of measurement disability-adjusted life years (DALYs). The cases of microcephaly were obtained from the Zika national and departmental databases built by the National Public Health Surveillance System (SIVIGILA). Deaths attributed to microcephaly were estimated from previous studies. Finally, we calculated mortality rates and incidences, then we performed a sensitivity analysis under three scenarios (conservative, medium, and extreme) to estimate the DALYs. In the 2015-2016 period, 10,609.4 DALYs were caused by microcephaly associated with Zika in Colombia. 71% of the total DALYs were years of life lost and 29% were years lived with disability. Five out of 32 departments (Meta, Córdoba, Tolima, Valle del Cauca, and Norte de Santander) contributed 71% of total DALYs. The burden of microcephaly associated with Zika outweighed the burden of other congenital anomalies such as neural tube defects and Down syndrome in children aged between 0 and 4 years in Colombia. Public health efforts must be made to prevent and monitor these cases.
2015 年，寨卡病毒在哥伦比亚出现。这种虫媒病毒的出现给该国的公共卫生带来了挑战，因为它与小头症等先天性疾病有关。因此，我们估计了 2015-2016 年期间寨卡病毒相关小头症给哥伦比亚及其行政区带来的疾病负担。我们进行了一项探索性的生态研究，使用残疾调整生命年（DALYs）作为测量单位。小头症病例来自国家公共卫生监测系统（SIVIGILA）建立的寨卡国家和部门数据库。小头症死亡人数是根据先前的研究估计的。最后，我们计算了死亡率和发病率，然后在三种情景（保守、中等和极端）下进行了敏感性分析，以估计 DALYs。在 2015-2016 年期间，哥伦比亚因寨卡病毒相关小头症导致 10609.4 DALYs。总 DALYs 的 71%是生命损失年，29%是残疾生活年。32 个部门中的 5 个（Meta、Córdoba、Tolima、Valle del Cauca 和 Norte de Santander）占总 DALYs 的 71%。与寨卡病毒相关的小头症负担超过了哥伦比亚 0-4 岁儿童其他先天性异常（如神经管缺陷和唐氏综合征）的负担。必须采取公共卫生措施来预防和监测这些病例。
