Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
Methods Mol Biol. 2021;2236:67-75. doi: 10.1007/978-1-0716-1060-2_7.
Myeloid-derived suppressor cells (MDSC) are known to inhibit functions of T and NK cells. MDSC have been shown to be generated and to accumulate under chronic inflammatory conditions that are typical for cancer. Therefore, it would be highly beneficial to find ways to diminish the number and immunosuppressive functions of these cells in tumor-bearing hosts. Here we describe current protocols to deplete MDSC or induce their maturation in preclinical tumor models that could lead to the attenuation of their immunosuppressive functions.
髓系来源的抑制细胞（MDSC）已知能够抑制 T 细胞和 NK 细胞的功能。已经证明 MDSC 在慢性炎症条件下产生和积累，这些条件是癌症的典型特征。因此，找到减少肿瘤宿主中这些细胞数量和免疫抑制功能的方法将是非常有益的。在这里，我们描述了目前在临床前肿瘤模型中消耗 MDSC 或诱导其成熟的方案，这些方案可能导致其免疫抑制功能减弱。
