Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China.
J Leukoc Biol. 2021 Aug;110(2):257-270. doi: 10.1002/JLB.1MR0421-597RR. Epub 2021 Jun 2.
Immune cells such as T cells, macrophages, dendritic cells, and other immunoregulatory cells undergo metabolic reprogramming in cancer and inflammation-derived microenvironment to meet specific physiologic and functional demands. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are characterized by immunosuppressive activity, which plays a key role in host immune homeostasis. In this review, we have discussed the core metabolic pathways, including glycolysis, lipid and fatty acid biosynthesis, and amino acid metabolism in the MDSCs under various pathologic situations. Metabolic reprogramming is a determinant of the phenotype and functions of MDSCs, and is therefore a novel therapeutic possibility in various diseases.
免疫细胞，如 T 细胞、巨噬细胞、树突状细胞和其他免疫调节细胞，在癌症和炎症衍生的微环境中经历代谢重编程，以满足特定的生理和功能需求。髓系来源的抑制细胞（MDSCs）是一群不成熟的髓系细胞，其特征是具有免疫抑制活性，在宿主免疫稳态中发挥关键作用。在这篇综述中，我们讨论了 MDSCs 在各种病理情况下的核心代谢途径，包括糖酵解、脂质和脂肪酸合成以及氨基酸代谢。代谢重编程是 MDSCs 表型和功能的决定因素，因此是各种疾病的一种新的治疗可能性。
