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考虑特殊情况、共同决策和疾病负担的炎症性肠病无缝管理方法。

Approach to the Seamless Management of Inflammatory Bowel Disease, Considering Special Situations, Shared Decision-Making, and Disease Burden.

机构信息

Aoyama Medical Clinic, Kobe, Japan.

Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan,

出版信息

Digestion. 2021;102(1):12-17. doi: 10.1159/000511481. Epub 2020 Nov 25.

DOI:10.1159/000511481
PMID:33238288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7949202/
Abstract

BACKGROUND

While the number of inflammatory bowel disease (IBD) patients has been steadily increasing, a lot of effective treatments have become available, including biological drugs. However, there still exists no effective treatment universally for all types of IBD patients. We have continuously discussed "Total Care" for IBD patients in the 3 consecutive annual meetings of the Japanese Gastroenterological Association from the 14th meeting to the 16th meeting in 2018-2020.

SUMMARY

In the 14th meeting, we summarized cross-sectional issues under the title "From Total Care to Microbiota" as for their subthemes. In the 15th meeting, under the title of "Consensus and Pitfalls in Special Situations," we discussed the thiopurine treatment for the patients in their childhood or pregnancy and lactation period as well as the cytapheresis treatment for elderly patients. In the 16th meeting, under the title "Future Issues in Special Situations: Including Disease Burden," we discussed about the issues in childhood-onset IBD, including transitional care and the new option of combination of treatments in their adulthood and their disease burdens. Key Messages: "Total Care" for IBD patients should be considered from a broad perspective with shared decision-making. It is imperative to involve medical staff members for careful handling of a wide range of disease burdens.

摘要

背景

尽管炎症性肠病 (IBD) 患者的数量一直在稳步增加,并且有许多有效的治疗方法可供选择,包括生物药物。然而,目前还没有针对所有类型 IBD 患者的通用有效治疗方法。我们在 2018 年至 2020 年的日本胃肠病学会第 14 次至第 16 次年度会议上连续讨论了 IBD 患者的“全面护理”。

摘要

在第 14 次会议上,我们总结了以“从全面护理到微生物组”为标题的跨学科问题,作为其子主题。在第 15 次会议上,我们以“特殊情况下的共识和陷阱”为标题,讨论了儿童期或妊娠和哺乳期患者的硫嘌呤治疗以及老年患者的细胞分离治疗。在第 16 次会议上,我们以“特殊情况下的未来问题:包括疾病负担”为标题,讨论了儿童发病 IBD 的问题,包括过渡护理和成年期联合治疗的新选择及其疾病负担。关键信息:应从广泛的角度考虑 IBD 患者的“全面护理”,并进行共同决策。必须让医务人员参与进来,以认真处理各种疾病负担。

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本文引用的文献

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A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan.日本早发性炎症性肠病的多中心前瞻性调查
Digestion. 2021;102(3):368-376. doi: 10.1159/000507570. Epub 2020 May 18.
2
VALIDation of the IBD-Disk Instrument for Assessing Disability in Inflammatory Bowel Diseases in a French Cohort: The VALIDate Study.验证 IBD-Disk 工具在评估法国炎症性肠病队列中的残疾状况的有效性:VALIDate 研究。
J Crohns Colitis. 2020 Nov 7;14(11):1512-1523. doi: 10.1093/ecco-jcc/jjaa100.
3
Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn's disease.系统评价和荟萃分析:生物制剂早期治疗成人和儿童克罗恩病的疗效和安全性。
Aliment Pharmacol Ther. 2020 May;51(9):831-842. doi: 10.1111/apt.15685. Epub 2020 Mar 23.
4
Management of elderly ulcerative colitis in Japan.日本老年溃疡性结肠炎的治疗管理。
J Gastroenterol. 2019 Jul;54(7):571-586. doi: 10.1007/s00535-019-01580-y. Epub 2019 Apr 20.
5
Efficacy and safety of granulocyte adsorption apheresis in elderly patients with ulcerative colitis.粒细胞吸附单采术治疗老年溃疡性结肠炎患者的疗效与安全性
J Clin Apher. 2018 Aug;33(4):514-520. doi: 10.1002/jca.21631. Epub 2018 Apr 24.
6
Clinical differences between elderly-onset ulcerative colitis and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan.老年发病溃疡性结肠炎与非老年发病溃疡性结肠炎的临床差异:日本全国性调查数据。
J Gastroenterol Hepatol. 2018 Nov;33(11):1839-1843. doi: 10.1111/jgh.14263. Epub 2018 May 16.
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Safety and efficacy of leukocytapheresis in elderly patients with ulcerative colitis: The impact in steroid-free elderly patients.白细胞去除术在老年溃疡性结肠炎患者中的安全性和疗效:对无类固醇治疗的老年患者的影响。
J Gastroenterol Hepatol. 2018 Aug;33(8):1485-1491. doi: 10.1111/jgh.14116. Epub 2018 Mar 4.
8
European Crohn's and Colitis Organisation Topical Review on IBD in the Elderly.欧洲克罗恩病和结肠炎组织老年 IBD 专题综述。
J Crohns Colitis. 2017 Mar 1;11(3):263-273. doi: 10.1093/ecco-jcc/jjw188. Epub 2016 Oct 20.
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