Liu David T, Schwarz-Nemec Ursula, Renner Bertold, Mueller Christian A, Besser Gerold
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Diagnostics (Basel). 2020 Nov 23;10(11):989. doi: 10.3390/diagnostics10110989.
The opacification of the olfactory cleft (OC) has been associated with birhinal orthonasal olfaction in patients with chronic rhinosinusitis (CRS). The aim of this study was to determine the associations between monorhinal and birhinal orthonasal, and retronasal olfaction with radiological markers of the OC in a cohort of patients with CRS. Results were analyzed in a CRS-cohort including 13 patients with nasal polyposis (CRSwNP) and 12 patients with non-eosinophilic CRS (non-eCRS). Monorhinal and birhinal orthonasal olfactory function, and OC-air volume were higher in non-eCRS compared CRSwNP. OC-opacification was also higher in CRSwNP compared to non-eCRS. In the entire CRS-cohort, those with higher OC-opacification showed significantly lower orthonasal and retronasal olfactory test results compared to those with lower OC-opacification across all three coronal planes. Similarly, higher unilateral OC-opacification was also associated with lower ipsilateral orthonasal olfactory function. Correlation analysis further revealed a positive correlation between monorhinal and birhinal orthonasal olfaction with ipsilateral and overall OC-air volume. Likewise, birhinal and monorhinal orthonasal, and retronasal olfactory test results correlated negatively with the overall and ipsilateral Lund-Mackay scores. Monorhinal and birhinal orthonasal, and retronasal olfactory function were lower in CRS patients with higher ipsilateral and overall OC-opacification compared to those with lower OC-opacification.
慢性鼻窦炎（CRS）患者中，嗅裂（OC）的浑浊与双侧经鼻嗅觉相关。本研究旨在确定一组CRS患者中单侧和双侧经鼻嗅觉以及鼻后嗅觉与OC放射学标志物之间的关联。对一个CRS队列进行了结果分析，该队列包括13例鼻息肉病患者（CRSwNP）和12例非嗜酸性CRS患者（非eCRS）。与CRSwNP相比，非eCRS患者的单侧和双侧经鼻嗅觉功能以及OC气腔容积更高。与非eCRS相比，CRSwNP患者的OC浑浊程度也更高。在整个CRS队列中，与所有三个冠状面中OC浑浊程度较低的患者相比，OC浑浊程度较高的患者经鼻和鼻后嗅觉测试结果显著更低。同样，较高的单侧OC浑浊也与同侧经鼻嗅觉功能较低有关。相关性分析进一步揭示，单侧和双侧经鼻嗅觉与同侧及整体OC气腔容积呈正相关。同样，双侧和单侧经鼻以及鼻后嗅觉测试结果与整体和同侧的Lund-Mackay评分呈负相关。与OC浑浊程度较低的CRS患者相比，同侧和整体OC浑浊程度较高的CRS患者的单侧和双侧经鼻以及鼻后嗅觉功能更低。
