Tobacco Science Research Center, Japan Tobacco Inc, 6-2 Umegaoka, Aoba, Yokohama, Kanagawa, 227-8512, Japan.
Tobacco Science Research Center, Japan Tobacco Inc, 6-2 Umegaoka, Aoba, Yokohama, Kanagawa, 227-8512, Japan.
Biochem Biophys Res Commun. 2021 Jan 1;534:547-552. doi: 10.1016/j.bbrc.2020.11.046. Epub 2020 Nov 22.
In this study, we investigated the activation of Transient receptor potential vanilloid subtype 1, TRPV1, by lactones, a representative flavor ingredient currently used for foods and beverages. As a result, we found that some lactones having C4 acyl chain length, γ-octalactone, δ-nonalactone and β-methyl-γ-octalactone, γ-undecalactone with C7 acyl chain length and δ-undecalactone with C6 acyl chain length activated TRPV1. TRPV1 is known as a non-selective cation channels that respond to a wide range of physical and chemical stimuli such as high temperature, protons, capsaicin and so on. Furthermore, it has been also demonstrated that activation of TRPV1 induced energy expenditure enhancement and thermogenesis, suppressed accumulation of visceral fat in mice and prevented non-alcoholic fatty acid liver. Thus, lactones that function as TRPV1 agonists are thought to be important candidates for decreasing the risks of developing a metabolic syndrome.
在这项研究中，我们研究了 Transient receptor potential vanilloid subtype 1（TRPV1）的激活情况，这些化合物是目前用于食品和饮料的代表性风味成分。结果发现，一些具有 C4 酰链长度的内酯，γ-辛内酯、δ-壬内酯和β-甲基-γ-辛内酯、C7 酰链长度的γ-十一内酯和 C6 酰链长度的δ-十一内酯激活了 TRPV1。TRPV1 是一种非选择性阳离子通道，对多种物理和化学刺激物有反应，如高温、质子、辣椒素等。此外，还证明了 TRPV1 的激活诱导了能量消耗的增强和产热，抑制了小鼠内脏脂肪的积累，并防止了非酒精性脂肪肝。因此，作为 TRPV1 激动剂的内酯被认为是降低代谢综合征风险的重要候选物。
