Arendt T, Bigl V
Paul Flechsig Institute of Brain Research, Department of Neurochemistry, Karl Marx University, Leipzig, GDR.
Neurobiol Aging. 1987 Nov-Dec;8(6):552-4. doi: 10.1016/0197-4580(87)90131-x.
With the example of the basal forebrain cholinergic system as a site of primary importance in AD, the existence of a critical neuron loss as a threshold between normal aging and AD is suggested. If the extent of degeneration exceeds this threshold the system decompensates and the clinical picture becomes apparent. The fully developed stage of AD might, therefore, represent a condition beyond the capacity of compensation where plastic adaptive changes are still present but functionally insufficient.
以前脑基底胆碱能系统作为阿尔茨海默病中一个至关重要的部位为例，提示存在一种关键的神经元丢失，它是正常衰老与阿尔茨海默病之间的一个阈值。如果退化程度超过这个阈值，该系统就会失代偿，临床症状就会显现出来。因此，阿尔茨海默病的充分发展阶段可能代表一种超出代偿能力的状态，此时仍存在可塑性适应性变化，但功能上不足。
