Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Kumiai Kosei Hospital, Takayama, Gifu, 5068502, Japan.
Sci Rep. 2020 Nov 25;10(1):20524. doi: 10.1038/s41598-020-77415-1.
Parkinson's disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health check-up data before and after the onset of motor symptoms between male and female PD patients and healthy subjects. We enrolled 22 male and 23 female PD patients and 60 male and 60 female healthy controls. A mixed-effects model was used to estimate the trajectory of each clinical marker over the years before and after motor symptoms onset in the PD subjects, which were then compared with the trajectories of the healthy controls. The results showed a premotor blood pressure increase in female PD patients and premotor decreases in haematocrit, total cholesterol and low-density lipoprotein cholesterol in the male patients. Our results indicated that blood pressure, haematocrit and serum cholesterol levels are potential premotor markers of PD. Additionally, the changes in anthropometric and serological indices before PD motor symptoms onset were sex specific.
帕金森病（PD）是一种使人衰弱的神经退行性疾病，其非运动症状，如便秘和嗅觉减退，在运动症状出现前 20 年就已经出现。本研究旨在确定 PD 运动前期的生物标志物。我们评估了男性和女性 PD 患者以及健康受试者在运动症状出现前后，从健康检查数据中获得的人体测量和血清学指标的纵向变化差异。我们纳入了 22 名男性和 23 名女性 PD 患者，以及 60 名男性和 60 名女性健康对照者。采用混合效应模型来估计 PD 患者在运动症状出现前后几年中每个临床标志物的轨迹，然后将这些轨迹与健康对照者的轨迹进行比较。结果显示，女性 PD 患者出现了运动前期的血压升高，而男性患者则出现了运动前期的血细胞比容、总胆固醇和低密度脂蛋白胆固醇降低。我们的研究结果表明，血压、血细胞比容和血清胆固醇水平可能是 PD 的运动前期生物标志物。此外，PD 运动症状出现前的人体测量和血清学指标的变化具有性别特异性。
