Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan.
Sci Rep. 2020 Nov 25;10(1):20552. doi: 10.1038/s41598-020-77633-7.
To evaluate a new method of measuring the intraocular pressure (IOP) in the vitreous cavity. IOPs in the anterior chamber and vitreous cavities of 24 porcine eyes (12 eyes with lenses and 12 eyes without lenses) were measured directly, continuously, and simultaneously. We used a needle as a part of the pressure sensor to measure the anterior chamber IOP and a disk-shaped sensor to measure the vitreous cavity IOP. A significant group-by-condition interaction on the vitreous cavity IOP between the two groups (phakia and aphakia) and four conditions of anterior chamber IOP were observed (F[3,258] = 5.8564, p < 0.001). A positive correlation was observed between the vitreous cavity IOP and anterior chamber IOP in both the phakia group (R = 0.96, p < 0.001) and the aphakia group (R = 0.97, p < 0.001). No significant correlation was observed between the ΔIOPv-a (vitreous cavity IOP - anterior chamber IOP) and anterior chamber IOP in either group (phakia group: R = - 0.18, p = 0.034; aphakia group: R = - 0.029, p = 0.73). The vitreous cavity IOP measured with the new sensor was well-correlated with the anterior chamber IOP in the physiological range tested.
评估一种新的玻璃体腔内眼压（IOP）测量方法。直接、连续、同时测量了 24 只猪眼（12 只带晶状体眼和 12 只无晶状体眼）的前房和玻璃体腔 IOP。我们使用针作为压力传感器的一部分来测量前房 IOP，使用盘状传感器来测量玻璃体腔 IOP。在前房 IOP 的四种情况下，两组（有晶状体和无晶状体）之间的玻璃体腔 IOP 存在显著的组间条件交互作用（F[3,258] = 5.8564，p < 0.001）。在有晶状体组（R = 0.96，p < 0.001）和无晶状体组（R = 0.97，p < 0.001）中，均观察到玻璃体腔 IOP 与前房 IOP 之间存在正相关。在两组中，ΔIOPv-a（玻璃体腔 IOP-前房 IOP）与前房 IOP 之间均未观察到显著相关性（有晶状体组：R = - 0.18，p = 0.034；无晶状体组：R = - 0.029，p = 0.73）。新传感器测量的玻璃体腔 IOP 与所测试的生理范围内的前房 IOP 具有良好的相关性。
