Roca María, Rodriguez Varela Ana, Carvajal Eva, Donat Ester, Cano Francisco, Armisen Ana, Vaya Maria Jose, Ekoff Helena, Hervas David, Rydell Niclas, Ribes-Koninckx Carmen
Celiac Disease and Digestive Immunopathology Unit, Instituto de Investigación Sanitaria La Fe, P.O. Box 46026, Valencia, Spain.
Primary Health Care Center of Betera, P.O. Box 46117, Bétera, Valencia, Spain.
Sci Rep. 2020 Nov 25;10(1):20565. doi: 10.1038/s41598-020-77625-7.
Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4-16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut-off levels could be conclusively recommended. A prospective study was conducted to investigate fCP concentrations of healthy children aged 4-16 years. In 212 healthy children, the median and 95th percentile for fCP were 18.8 mg/kg and 104.5 mg/kg, respectively. We found a statistically significant association between the 95th percentile of fCP concentrations and age (p < 0.001). We propose a nomogram to facilitate the interpretation of fCP results in children aged 4-16 years. Further studies are required to validate the proposed values in clinical practice.
粪便钙卫蛋白（fCP）的参考值在儿童中尚未得到令人信服的确立。我们旨在调查更多4至16岁健康儿童群体中的fCP浓度，以更深入地分析该年龄范围内fCP的变化情况，并确定是否可以明确推荐临界值水平。我们进行了一项前瞻性研究，以调查4至16岁健康儿童的fCP浓度。在212名健康儿童中，fCP的中位数和第95百分位数分别为18.8mg/kg和104.5mg/kg。我们发现fCP浓度的第95百分位数与年龄之间存在统计学上的显著关联（p<0.001）。我们提出了一个列线图，以方便解读4至16岁儿童的fCP检测结果。需要进一步的研究来在临床实践中验证所提出的值。
