Freeman L N, Schachat A P, Knox D L, Michels R G, Green W R
Wilmer Ophthalmological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Ophthalmology. 1987 Dec;94(12):1631-9. doi: 10.1016/s0161-6420(87)33256-7.
The authors report 32 cases of histologically proven ocular reticulum cell sarcoma (RCS). Follow-up data are available for all patients. Twenty-six patients (81%) have died and the mean survival time was 20 months from the time of diagnosis of RCS. Diagnosis of ocular involvement was made by vitreous biopsy in 56% of cases, enucleation in 13%, and postmortem examination in 31%. The mean age at the time of diagnosis was 60 years. Central nervous system (CNS) involvement was present in 56% of patients, visceral involvement in 16%, and both CNS and visceral involvement in 6%. Isolated ocular disease occurred in 22% of patients. Results of head computed tomography (CT) and cerebrospinal fluid examination more often disclosed evidence of RCS than did body CT or nuclear medicine scans. Responses to treatment were variable, but prognosis for survival is poor.
作者报告了32例经组织学证实的眼网状细胞肉瘤（RCS）。所有患者均有随访数据。26例患者（81%）已死亡，自RCS诊断之时起平均生存时间为20个月。56%的病例通过玻璃体活检确诊眼部受累，13%通过眼球摘除术确诊，31%通过尸检确诊。诊断时的平均年龄为60岁。56%的患者存在中枢神经系统（CNS）受累，16%存在内脏受累，6%同时存在CNS和内脏受累。22%的患者为单纯眼部疾病。头部计算机断层扫描（CT）和脑脊液检查结果比身体CT或核医学扫描更常显示RCS的证据。治疗反应各不相同，但生存预后较差。
