Char D H, Ljung B M, Miller T, Phillips T
Department of Ophthalmology, University of California, San Francisco 94143.
Ophthalmology. 1988 May;95(5):625-30. doi: 10.1016/s0161-6420(88)33145-3.
The authors retrospectively reviewed the diagnosis and management of 20 intraocular lymphoma patients who initially presented with either ocular or central nervous system (CNS) disease. As the ophthalmic community has become more aware of this entity, the interval between symptoms and diagnosis has significantly shortened. Diagnosis can usually be made on cytopathologic examination of vitreous cells. However, in three cases more than one vitreous biopsy was necessary. Results of cytologic examination appeared to be more accurate than those of conventional lymphocyte surface marker studies in the diagnosis of an intraocular lymphoma. Long-term survival occurred in some patients treated with a combination of intrathecal chemotherapy and ocular/CNS irradiation.
作者回顾性分析了20例最初表现为眼部或中枢神经系统（CNS）疾病的眼内淋巴瘤患者的诊断和治疗情况。随着眼科界对该疾病的认识不断提高，症状出现至诊断的时间间隔已显著缩短。通常可通过玻璃体细胞的细胞病理学检查做出诊断。然而，有3例患者需要进行不止一次的玻璃体活检。在眼内淋巴瘤的诊断中，细胞学检查结果似乎比传统淋巴细胞表面标志物研究结果更准确。一些接受鞘内化疗联合眼部/中枢神经系统放疗的患者实现了长期生存。
