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锶改性分级微/纳结构钛植入物的制备与性能。

The Fabrication and Function of Strontium-modified Hierarchical Micro/Nano Titanium Implant.

机构信息

Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, 250012, People's Republic of China.

Osaka Dental University Kusuha School, Hirakata City, Osaka 573-1121, Japan.

出版信息

Int J Nanomedicine. 2020 Nov 16;15:8983-8998. doi: 10.2147/IJN.S268657. eCollection 2020.

DOI:10.2147/IJN.S268657
PMID:33239873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7682802/
Abstract

BACKGROUND

Relying on surface topography alone to enhance the osteointegration of implants is still inadequate. An effective way to combine long-term ion release and surface topography to enhance osteogenic property is urgently needed.

PURPOSE

The objective of this study is to fabricate a long-term strontium ion release implant system and confirm the biological function in vitro and in vivo.

METHODS

The biomimic surface was fabricated through alkali-heat treatment and magnetron sputtering. The in vitro biological function assays were determined by MTT, fluorescence staining, alkaline phosphatase activity, extracellular mineralization, and quantitative real-time polymerase chain reaction assays. The in vivo experiments were detected by micro-CT, HE staining and Masson staining.

RESULTS

The biomimic surface structure has been successfully fabricated. The in vitro cell assays determined that AH-Ti/Sr90 possessed the best biological function. The in vivo experiments demonstrated that AH-Ti/Sr90 could promote osteointegration significantly under both in normal and osteoporotic conditions.

CONCLUSION

We determined that AH-Ti/Sr90 possesses the best osteogenic property, long-term ion release capacity and osteointegration promotion ability. It has potential clinic application prospects.

摘要

背景

仅依靠表面形貌来增强种植体的骨整合仍然不够。迫切需要一种有效的方法将长期离子释放和表面形貌结合起来，以增强成骨特性。

目的

本研究旨在制备一种长期释放锶离子的植入物系统，并在体外和体内确认其生物学功能。

方法

通过碱热处理和磁控溅射制备仿生表面。通过 MTT、荧光染色、碱性磷酸酶活性、细胞外矿化和实时定量聚合酶链反应测定体外生物功能。通过 micro-CT、HE 染色和 Masson 染色检测体内实验。

结果

成功制备了仿生表面结构。体外细胞实验表明，AH-Ti/Sr90 具有最佳的生物学功能。体内实验表明，在正常和骨质疏松条件下，AH-Ti/Sr90 均可显著促进骨整合。

结论

我们确定 AH-Ti/Sr90 具有最佳的成骨特性、长期离子释放能力和促进骨整合能力。它具有潜在的临床应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/82d5edc37313/IJN-15-8983-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/a1b665edcdf5/IJN-15-8983-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/541ce3443bb8/IJN-15-8983-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/c50af5a64321/IJN-15-8983-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/afc4fa45ce11/IJN-15-8983-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/4c7e6bfd4a75/IJN-15-8983-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/eb99c4177b20/IJN-15-8983-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/c9f9b8ef6c47/IJN-15-8983-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/82d5edc37313/IJN-15-8983-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/a1b665edcdf5/IJN-15-8983-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/541ce3443bb8/IJN-15-8983-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/c50af5a64321/IJN-15-8983-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/afc4fa45ce11/IJN-15-8983-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/4c7e6bfd4a75/IJN-15-8983-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/eb99c4177b20/IJN-15-8983-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/c9f9b8ef6c47/IJN-15-8983-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cb3/7682802/82d5edc37313/IJN-15-8983-g0008.jpg

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