Ribári O, Sziklai I, Kiss G J
Department of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University Medical School, Budapest, Hungary.
ORL J Otorhinolaryngol Relat Spec. 1987;49(6):282-6. doi: 10.1159/000275953.
The otosclerotic stapes footplate exhibits higher activities of cathepsin D and H and collagenase-like peptidase than those of normal cortical bone. The elevated enzyme activities of osteoblastic origin (Cl-peptidase and cathepsin D) emphasize the essential and probably primary role of the bone-forming cells, not only in bone formation, but in resorption as well. The highest activity of cathepsin D from among the measured enzymes highlights the adjuvant role of acidic glucosaminoglycans in the otosclerotic demineralization process. As the osteoblastic osteoid synthesis is known to be sharply reduced in otosclerotic bone remodelling, and the above data emphasize the role of proteolytic enzymes of osteoblastic origin too, indirectly, osteoblasts seem to be the otosclerosis signal-transducing cells.
耳硬化镫骨底板中组织蛋白酶D和H以及类胶原酶肽酶的活性高于正常皮质骨。成骨细胞来源的酶活性升高（Cl-肽酶和组织蛋白酶D）强调了骨形成细胞不仅在骨形成中，而且在骨吸收中所起的重要且可能是主要的作用。在所测酶中，组织蛋白酶D的活性最高，突出了酸性氨基葡聚糖在耳硬化脱矿过程中的辅助作用。由于已知在耳硬化骨重塑过程中，成骨细胞类骨质合成急剧减少，且上述数据也间接强调了成骨细胞来源的蛋白水解酶的作用，因此成骨细胞似乎是耳硬化信号转导细胞。
