Sziklai I, Ribári O
ORL Clinic, Semmelweis Medical University Budapest, Hungary.
Acta Otolaryngol. 1995 Mar;115(2):296-9. doi: 10.3109/00016489509139313.
The beneficial role of bioflavonoids in an otosclerosis-like bone-remodelling process can be implicated from its interference with bone resorption induced by prostaglandin E2 (PGE2) in cultured guinea pig ossicles. Ipriflavone (7-isopropoxy-isoflavon) and quercetin reduced PGE2-elevated collagenase-like peptidase (Cl-peptidase) activity and potentiated a PGE2-induced decrease in collagen synthesis. The fact that PGE2 effects are mediated through cyclic AMP in bone turnover and flavonoids act synergistically with PGE2 in collagen synthesis confirm a cyclic AMP phosphodiesterase inhibitory role of flavonoids. It has already been attempted to use Ipriflavone medical treatment of otosclerosis. Quercetin, which has a better than Ipriflavone water-solubility seems as promising as Ipriflavone in the control of the otosclerotic bone-remodelling disturbance.
生物类黄酮在耳硬化症样骨重塑过程中的有益作用，可以从其对培养的豚鼠听小骨中前列腺素E2（PGE2）诱导的骨吸收的干扰中得到暗示。依普黄酮（7-异丙氧基异黄酮）和槲皮素降低了PGE2升高的胶原酶样肽酶（Cl-肽酶）活性，并增强了PGE2诱导的胶原合成减少。PGE2的作用是通过环磷酸腺苷（cAMP）介导骨转换，且类黄酮在胶原合成中与PGE2协同作用，这一事实证实了类黄酮具有环磷酸腺苷磷酸二酯酶抑制作用。人们已经尝试使用依普黄酮对耳硬化症进行药物治疗。槲皮素的水溶性优于依普黄酮，在控制耳硬化性骨重塑紊乱方面似乎与依普黄酮一样有前景。
