Hergueta-Redondo Marta, Peinado Héctor
Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
EJC Suppl. 2020 Aug 22;15:38-48. doi: 10.1016/j.ejcsup.2019.09.001. eCollection 2020 Aug.
Ovarian cancer cells mainly metastasise within the peritoneal cavity, the lethal consequence of tumour progression in this cancer type. Classically, changes in tumour cells, such as epithelial to mesenchymal transition, involve the down-regulatinon of E-cadherin, activation of extracellular proteases and integrin-mediated adhesion. However, our current understanding of ovarian tumour progression suggests the implication of both intrinsic and extrinsic factors. It has been proposed that ovarian cancer metastases are a consequence of the crosstalk between cancer cells and the tumour microenvironment by soluble factors and extracellular vesicles. Characterisation of the alterations in both the tumour cells and the surrounding microenvironment has emerged as a new research field to understand ovarian cancer metastasis. In this mini review, we will summarise the most recent findings, focusing our attention on the role of secreted factors and extracellular vesicles in ovarian cancer metastasis.
卵巢癌细胞主要在腹腔内转移，这是这种癌症类型肿瘤进展的致命后果。传统上，肿瘤细胞的变化，如上皮-间质转化，涉及E-钙黏蛋白的下调、细胞外蛋白酶的激活和整合素介导的黏附。然而，我们目前对卵巢肿瘤进展的理解表明，内在因素和外在因素都有影响。有人提出，卵巢癌转移是癌细胞与肿瘤微环境通过可溶性因子和细胞外囊泡相互作用的结果。对肿瘤细胞和周围微环境变化的表征已成为理解卵巢癌转移的一个新研究领域。在本综述中，我们将总结最新发现，重点关注分泌因子和细胞外囊泡在卵巢癌转移中的作用。
