Glick Matthew, Baxter Chase, Lopez David, Mufti Kashif, Sawada Stephen, Lahm Tim
Internal Medicine Residency Program, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.
Department of Medicine, Division of Rheumatology, Indiana University School of Medicine, Indianapolis, USA.
Pulm Circ. 2020 Nov 11;10(4):2045894020960967. doi: 10.1177/2045894020960967. eCollection 2020 Oct-Dec.
Immune checkpoint inhibitors successfully treat various malignancies by inducing an immune response to tumor cells. However, their use has been associated with a variety of autoimmune disorders, such as diabetes, hepatitis, and pneumonitis. Pulmonary arterial hypertension due to checkpoint inhibitor use has not yet been described. We present a novel case of pulmonary arterial hypertension associated with systemic lupus erythematosus and Sjogren's syndrome overlap that was induced by therapy with the checkpoint inhibitor durvalumab.
免疫检查点抑制剂通过诱导对肿瘤细胞的免疫反应成功治疗各种恶性肿瘤。然而，它们的使用与多种自身免疫性疾病有关，如糖尿病、肝炎和肺炎。使用检查点抑制剂导致的肺动脉高压尚未见报道。我们报告了一例由检查点抑制剂度伐利尤单抗治疗诱发的、与系统性红斑狼疮和干燥综合征重叠相关的肺动脉高压新病例。
