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肺毛霉病:一例报告。

Pulmonary mucormycosis: A case report.

作者信息

Novais António Grilo, Capelo Joana, Costa Marta, Conceição Mariana, Crespo Pedro, Mocho Luísa, Leão Beatriz, Malheiro Luís, Silva Susana, Sarmento António

机构信息

Internal Medicine Department, Centro Hospitalar Tondela-Viseu, Portugal.

Pneumology Department, Centro Hospitalar Tondela-Viseu, Portugal.

出版信息

IDCases. 2020 Nov 1;22:e00993. doi: 10.1016/j.idcr.2020.e00993. eCollection 2020.

DOI:10.1016/j.idcr.2020.e00993
PMID:33240790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7674292/
Abstract

Mucormycosis is a rare fungal infection caused by Mucorales order fungi. The rhino-cerebral form of mucormycosis is most commonly seen in patients with diabetes mellitus, whereas, pulmonary mucormycosis is a rare manifestation in patients with haematological malignancy and transplant recipients. We report a case of pulmonary mucormycosis presenting with a late acute onset diabetes on a patient immunosuppressed with a low dose of steroids. We aim to illustrate the need for a high clinical suspicion for the diagnosis of mucormycosis and to report the importance of early and aggressive inhiation of antifungal therapy.

摘要

毛霉病是一种由毛霉目真菌引起的罕见真菌感染。鼻脑型毛霉病最常见于糖尿病患者,而肺毛霉病在血液系统恶性肿瘤患者和移植受者中是一种罕见表现。我们报告一例肺毛霉病病例,该患者在接受低剂量类固醇免疫抑制治疗时出现迟发性急性糖尿病。我们旨在说明对毛霉病诊断需要高度临床怀疑,并报告早期积极启动抗真菌治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/44f151efb0de/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/8cb504e92bd8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/f72208c4c15a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/7aa65d6350ab/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/44f151efb0de/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/8cb504e92bd8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/f72208c4c15a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/7aa65d6350ab/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6519/7674292/44f151efb0de/gr4.jpg

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本文引用的文献

1
Mucormycosis treatment: Recommendations, latest advances, and perspectives.毛霉病治疗:推荐意见、最新进展和展望。
J Mycol Med. 2020 Sep;30(3):101007. doi: 10.1016/j.mycmed.2020.101007. Epub 2020 Jun 20.
2
Understanding Mucormycoses in the Age of "omics".在“组学”时代理解毛霉病
Front Genet. 2020 Jun 30;11:699. doi: 10.3389/fgene.2020.00699. eCollection 2020.
3
Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.
一名患有肺部坏死性肿块的中年男性。
Lung India. 2023 Jul-Aug;40(4):360-361. doi: 10.4103/lungindia.lungindia_81_23.
4
Pulmonary mucormycosis after renal transplantation: A case report and a literature review.肾移植术后肺毛霉病:一例报告及文献复习
Ann Med Surg (Lond). 2022 Jun 1;78:103889. doi: 10.1016/j.amsu.2022.103889. eCollection 2022 Jun.
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Fatal Mucormycosis Post COVID-19 Infection in Uncontrolled Diabetes with Misuse of Glucocorticoids and Antibiotics.新冠病毒感染后,在未控制的糖尿病患者中因滥用糖皮质激素和抗生素导致的致命性毛霉病
Infect Drug Resist. 2022 Mar 18;15:1121-1126. doi: 10.2147/IDR.S356465. eCollection 2022.
全球毛霉病诊断和管理指南:欧洲医学真菌学会联合会与真菌感染研究组教育和研究联盟合作开展的一项倡议。
Lancet Infect Dis. 2019 Dec;19(12):e405-e421. doi: 10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5.
4
Factors affecting surgical resection and treatment outcomes in patients with pulmonary mucormycosis.影响肺毛霉病患者手术切除及治疗结果的因素。
J Thorac Dis. 2019 Mar;11(3):892-900. doi: 10.21037/jtd.2019.01.75.
5
Global Epidemiology of Mucormycosis.毛霉病的全球流行病学
J Fungi (Basel). 2019 Mar 21;5(1):26. doi: 10.3390/jof5010026.
6
Challenges in the diagnosis and treatment of mucormycosis.毛霉病诊断与治疗中的挑战。
Med Mycol. 2018 Apr 1;56(suppl_1):93-101. doi: 10.1093/mmy/myx101.
7
ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013.ESCMID 和 ECMM 联合临床指南:2013 年毛霉病的诊断和管理
Clin Microbiol Infect. 2014 Apr;20 Suppl 3:5-26. doi: 10.1111/1469-0691.12371.
8
Pulmonary fungal infections.肺部真菌感染。
Respirology. 2012 Aug;17(6):913-26. doi: 10.1111/j.1440-1843.2012.02150.x.
9
Combination therapy for mucormycosis: why, what, and how?联合治疗毛霉病:为什么、用什么、怎么用?
Clin Infect Dis. 2012 Feb;54 Suppl 1(Suppl 1):S73-8. doi: 10.1093/cid/cir885.
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Early clinical and laboratory diagnosis of invasive pulmonary, extrapulmonary, and disseminated mucormycosis (zygomycosis).侵袭性肺、肺外和播散性毛霉病(接合菌病)的早期临床和实验室诊断。
Clin Infect Dis. 2012 Feb;54 Suppl 1:S55-60. doi: 10.1093/cid/cir868.