精准医学在骨科生物膜感染的诊断与管理中的应用
Precision Medicine in the Diagnosis and Management of Orthopedic Biofilm Infections.
作者信息
Baldan Rossella, Sendi Parham
机构信息
Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Centre for Musculoskeletal Infections, University Hospital Basel, Basel, Switzerland.
出版信息
Front Med (Lausanne). 2020 Nov 10;7:580671. doi: 10.3389/fmed.2020.580671. eCollection 2020.
Abstract
Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections.
摘要
骨科生物膜感染难以治疗，需要多学科方法进行诊断和管理。该领域的最新进展包括破坏生物膜的方法、测序工具以及针对生物膜中细菌的抗生素敏感性测试。致病微生物生物膜特性的克隆间差异观察，以及对日益老龄化人群中共存疾病和多种药物治疗情况的考虑，都要求采用个性化方法来治疗这些感染。在本文中，我们重点介绍精准医学的各个方面，这些方面可能为骨科生物膜感染的诊断和管理开辟新的视角。
相似文献
1
Precision Medicine in the Diagnosis and Management of Orthopedic Biofilm Infections.精准医学在骨科生物膜感染的诊断与管理中的应用
Front Med (Lausanne). 2020 Nov 10;7:580671. doi: 10.3389/fmed.2020.580671. eCollection 2020.
2
Emerging Issues and Initial Insights into Bacterial Biofilms: From Orthopedic Infection to Metabolomics.细菌生物膜的新问题与初步见解：从骨科感染到代谢组学
Antibiotics (Basel). 2024 Feb 13;13(2):184. doi: 10.3390/antibiotics13020184.
3
Biofilm Disrupting Technology for Orthopedic Implants: What's on the Horizon?用于骨科植入物的生物膜破坏技术：未来的发展方向是什么？
Front Med (Lausanne). 2014 Aug 15;1:22. doi: 10.3389/fmed.2014.00022. eCollection 2014.
4
[The significance of biofilm for the treatment of infections in orthopedic surgery : 2017 Update].[生物膜在骨科手术感染治疗中的意义：2017年更新]
Unfallchirurg. 2017 Jun;120(6):461-471. doi: 10.1007/s00113-017-0361-y.
5
Biofilm formation and antimicrobial susceptibility of staphylococci and enterococci from osteomyelitis associated with percutaneous orthopaedic implants.骨水泥型假体相关骨髓炎中外源凝固酶阴性葡萄球菌和肠球菌的生物膜形成和抗菌药物敏感性。
J Biomed Mater Res B Appl Biomater. 2017 Nov;105(8):2630-2640. doi: 10.1002/jbm.b.33803. Epub 2016 Oct 25.
6
The role of bacterial biofilms in chronic infections.细菌生物膜在慢性感染中的作用。
APMIS Suppl. 2013 May(136):1-51. doi: 10.1111/apm.12099.
7
2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections.2018 年肌肉骨骼感染国际共识会议：生物膜工作组总结及生物膜相关肌肉骨骼感染共识
J Orthop Res. 2019 May;37(5):1007-1017. doi: 10.1002/jor.24229. Epub 2019 Feb 12.
8
Orthopaedic biofilm infections.骨科生物膜感染
APMIS. 2017 Apr;125(4):353-364. doi: 10.1111/apm.12687.
9
Investigation of biofilm production and its association with genetic and phenotypic characteristics of OM (osteomyelitis) and non-OM orthopedic Staphylococcus aureus.探讨生物膜形成及其与 OM（骨髓炎）和非 OM 骨科金黄色葡萄球菌的遗传和表型特征的关系。
Ann Clin Microbiol Antimicrob. 2020 Mar 26;19(1):10. doi: 10.1186/s12941-020-00352-4.
10
Antimicrobial susceptibility testing in biofilm-growing bacteria.生物膜生长细菌的药敏试验。
Clin Microbiol Infect. 2014 Oct;20(10):981-90. doi: 10.1111/1469-0691.12651. Epub 2014 Jun 14.
引用本文的文献
1
Biofilm Formation in Chronic Infections: A Comprehensive Review of Pathogenesis, Clinical Implications, and Novel Therapeutic Approaches.慢性感染中的生物膜形成：发病机制、临床意义及新型治疗方法的全面综述
Cureus. 2024 Oct 1;16(10):e70629. doi: 10.7759/cureus.70629. eCollection 2024 Oct.
2
Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections.对抗骨科植入物相关感染的抗菌涂层的最新进展
Molecules. 2024 Mar 6;29(5):1172. doi: 10.3390/molecules29051172.
3
Searching for Virulence Factors among Isolates from Orthopedic Infections: Correlation of , and Genes with Hemolytic Activity and Synergistic Hemolytic Activity.从骨科感染分离株中寻找毒力因子： 、 和 基因与溶血活性和协同溶血活性的相关性。
Int J Mol Sci. 2023 Oct 29;24(21):15724. doi: 10.3390/ijms242115724.
4
Molecular Characterization of Community- and Hospital- Acquired Methicillin-Resistant Isolates during COVID-19 Pandemic.COVID-19大流行期间社区获得性和医院获得性耐甲氧西林分离株的分子特征分析
Antibiotics (Basel). 2023 Jan 12;12(1):157. doi: 10.3390/antibiotics12010157.
5
Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection.脱矿生理学，第二部分：釉质白斑、龋洞和骨感染。
Curr Osteoporos Rep. 2022 Feb;20(1):106-119. doi: 10.1007/s11914-022-00723-0. Epub 2022 Feb 14.
6
Environmental, Microbiological, and Immunological Features of Bacterial Biofilms Associated with Implanted Medical Devices.植入医疗器械相关细菌生物膜的环境、微生物学和免疫学特征。
Clin Microbiol Rev. 2022 Apr 20;35(2):e0022120. doi: 10.1128/cmr.00221-20. Epub 2022 Jan 19.
本文引用的文献
1
Metagenomic next-generation sequencing of synovial fluid demonstrates high accuracy in prosthetic joint infection diagnostics: mNGS for diagnosing PJI.滑液的宏基因组下一代测序在人工关节感染诊断中显示出高准确性：用于诊断人工关节感染的宏基因组下一代测序。
Bone Joint Res. 2020 Aug 19;9(7):440-449. doi: 10.1302/2046-3758.97.BJR-2019-0325.R2. eCollection 2020 Jul.
2
Detecting the presence of bacteria in low-volume preoperative aspirated synovial fluid by metagenomic next-generation sequencing.采用宏基因组下一代测序技术检测小体积术前抽吸滑液中细菌的存在。
Int J Infect Dis. 2020 Oct;99:108-116. doi: 10.1016/j.ijid.2020.07.039. Epub 2020 Jul 25.
3
Metagenomic next generation sequencing improves diagnosis of prosthetic joint infection by detecting the presence of bacteria in periprosthetic tissues.宏基因组下一代测序通过检测假体周围组织中细菌的存在来提高假体关节感染的诊断。
Int J Infect Dis. 2020 Jul;96:573-578. doi: 10.1016/j.ijid.2020.05.125. Epub 2020 Jun 4.
4
Preliminary assessment of nanopore-based metagenomic sequencing for the diagnosis of prosthetic joint infection.基于纳米孔的宏基因组测序在人工关节感染诊断中的初步评估。
Int J Infect Dis. 2020 Aug;97:54-59. doi: 10.1016/j.ijid.2020.05.044. Epub 2020 May 19.
5
Bacterial toxins in musculoskeletal infections.肌肉骨骼感染中的细菌毒素。
J Orthop Res. 2021 Feb;39(2):240-250. doi: 10.1002/jor.24683. Epub 2020 Apr 14.
6
Comparison of broad-range polymerase chain reaction and metagenomic next-generation sequencing for the diagnosis of prosthetic joint infection.广谱聚合酶链反应与宏基因组下一代测序在人工关节感染诊断中的比较。
Int J Infect Dis. 2020 Jun;95:8-12. doi: 10.1016/j.ijid.2020.03.055. Epub 2020 Apr 3.
7
Can metagenomic next-generation sequencing identify the pathogens responsible for culture-negative prosthetic joint infection?宏基因组下一代测序能鉴定出培养阴性假体关节感染的病原体吗？
BMC Infect Dis. 2020 Mar 30;20(1):253. doi: 10.1186/s12879-020-04955-2.
8
Second Periprosthetic Joint Infection Caused by : How Genomic Sequencing Can Help Defining the Best Therapeutic Strategy.由……引起的二期人工关节感染：基因组测序如何有助于确定最佳治疗策略
Front Med (Lausanne). 2020 Feb 21;7:53. doi: 10.3389/fmed.2020.00053. eCollection 2020.
9
Adjuvant antibiotic-loaded bone cement: Concerns with current use and research to make it work.抗生素骨水泥作为骨植入物的应用：当前使用及相关研究的关注焦点
J Orthop Res. 2021 Feb;39(2):227-239. doi: 10.1002/jor.24616. Epub 2020 Mar 2.
10
MBEC Versus MBIC: the Lack of Differentiation between Biofilm Reducing and Inhibitory Effects as a Current Problem in Biofilm Methodology.最低生物被膜消除浓度（MBEC）与最低生物被膜抑制浓度（MBIC）：生物被膜减少和抑制作用之间缺乏区分作为生物被膜方法学中的当前问题
Biol Proced Online. 2019 Sep 13;21:18. doi: 10.1186/s12575-019-0106-0. eCollection 2019.
Zotero 插件