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支气管扩张的临床表型及其临床指导意义。

The clinical phenotype of bronchiectasis and its clinical guiding implications.

机构信息

Department of Pulmonary and Critical Care Medicine, the First Hospital, 74648Shanxi Medical University, Shanxi 030001, China.

School of Basic Medicine, Basic Medical Science Center, 74648Shanxi Medical University, Shanxi 030600, China.

出版信息

Exp Biol Med (Maywood). 2021 Feb;246(3):275-280. doi: 10.1177/1535370220972324. Epub 2020 Nov 26.

Abstract

Bronchiectasis is a chronic airway disease with abnormal and persistent bronchial dilatation caused by a variety of reasons. In recent years, numerous reports have shown that bronchiectasis is heterogeneous, the clinical characteristics of patients with different phenotypes are different, and the efficacy of a treatment regimen may vary greatly in patients with different bronchiectasis phenotypes. This paper summarizes the current clinical phenotypic classification of bronchiectasis from the perspective of etiology, microbiology, and the frequency of acute exacerbation, and cluster analysis was used to determine new clinical phenotypes and their statistical and clinical significance. Different tools for assessing disease severity yield different outcomes. This article summarizes the research progress in the above areas, hoping to provide a more comprehensive understanding of the disease.

摘要

支气管扩张症是一种慢性气道疾病,由多种原因引起的支气管异常和持续扩张。近年来,大量报道表明支气管扩张症具有异质性,不同表型患者的临床特征不同,不同支气管扩张症表型患者的治疗方案疗效差异很大。本文从病因、微生物学和急性加重频率的角度总结了支气管扩张症的目前临床表型分类,并采用聚类分析确定了新的临床表型及其统计学和临床意义。评估疾病严重程度的不同工具产生不同的结果。本文总结了上述领域的研究进展,希望能提供对该疾病更全面的认识。

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引用本文的文献

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