Pisetsky D S
Durham Veterans Administration Hospital, North Carolina.
Rheum Dis Clin North Am. 1987 Dec;13(3):569-81.
Recent investigations on the mechanisms of ANA production in the rheumatic diseases suggest that these responses frequently emerge in the setting of nonspecific immunoregulatory disturbances. However, the expansion and maturation of these responses to generate pathogenic specificities may require the coexistence of clonal or antigen-specific abnormalities. At the genetic level, ANAs appear to be of diverse origin, including some with representation in the normal B cell repertoire. Since some ANAs are disease-specific, elucidation of the basis of their production should provide insights into the unique pathogenetic features of different rheumatic diseases.
近期关于自身抗体（ANA）在风湿性疾病中产生机制的研究表明，这些反应常在非特异性免疫调节紊乱的背景下频繁出现。然而，这些反应的扩展和成熟以产生致病性特异性可能需要克隆性或抗原特异性异常的共存。在基因水平上，自身抗体似乎有多种起源，包括一些在正常B细胞库中存在的抗体。由于一些自身抗体具有疾病特异性，阐明其产生的基础应能为不同风湿性疾病独特的发病机制特征提供见解。
