Klein Beate, Silberbauer Christoph
Abteilung für Psychiatrie und Psychotherapeutische Medizin, Salzkammergut Klinikum Vöcklabruck, Dr.-Wilhelm-Bock-Straße 1, 4840, Vöcklabruck, Österreich.
Neuropsychiatr. 2021 Jun;35(2):98-101. doi: 10.1007/s40211-020-00377-3. Epub 2020 Nov 26.
Rhabdomyolysis is defined by disintegration of skeletal muscle fibres. Clinical presentation varies and is mostly associated with myalgias as well as elevation of creatine kinase in the serum. Mechanical damage, toxic medicinal factors, and predisposing factors such as myopathies may trigger the condition. This report describes a case of rhabdomyolysis uncovered by chance after administration of paliperidonepalmitate as depot medication in a 45 years old schizophrenic male patient after having tolerated oral risperidone without any problems. Routine screening for clinical manifestations and serum-creatin kinase maybe essential in unravelling antipsychotic-induced rhabdomyolysis.
横纹肌溶解症的定义是骨骼肌纤维解体。临床表现各异，主要与肌痛以及血清肌酸激酶升高有关。机械损伤、有毒药物因素以及诸如肌病等诱发因素可能引发该病。本报告描述了一例45岁男性精神分裂症患者在口服利培酮无任何问题后，使用棕榈酸帕利哌酮长效针剂治疗时意外发现横纹肌溶解症的病例。对临床表现和血清肌酸激酶进行常规筛查可能对揭示抗精神病药物诱发的横纹肌溶解症至关重要。
