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一项综合分析确定了 COVID-19 中涉及的转录特征和关键基因。

An integrative analysis identifying transcriptional features and key genes involved in COVID-19.

机构信息

Laboratory of Allergy & Inflammation, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.

Department of Pulmonary and Critical Care Medicine, Sub-center of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Chongqing Medical University, Chengdu 610031, China.

出版信息

Epigenomics. 2020 Nov;12(22):1969-1981. doi: 10.2217/epi-2020-0168. Epub 2020 Nov 26.

DOI:10.2217/epi-2020-0168
PMID:33242255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7714049/
Abstract

To elucidate the transcriptional characteristics of COVID-19. We utilized an integrative approach to comprehensively analyze the transcriptional features of both COVID-19 patients and SARS-CoV-2 infected cells. Widespread infiltration of immune cells was observed. We identified 233 genes that were codifferentially expressed in both bronchoalveolar lavage fluid and lung samples of COVID-19 patients. Functional analysis suggested upregulated genes were related to immune response such as neutrophil activation and antivirus response, while downregulated genes were associated with cell adhesion. Finally, we identified , and as core genes during SARS-CoV-2 infection. The identification of core genes involved in COVID-19 can provide us with more insights into the molecular features of COVID-19.

摘要

为了阐明 COVID-19 的转录特征。我们采用了一种综合的方法来全面分析 COVID-19 患者和 SARS-CoV-2 感染细胞的转录特征。观察到免疫细胞广泛浸润。我们在 COVID-19 患者的支气管肺泡灌洗液和肺组织样本中鉴定出 233 个差异表达的基因。功能分析表明，上调的基因与免疫反应有关，如中性粒细胞的激活和抗病毒反应，而下调的基因与细胞黏附有关。最后，我们鉴定出、和在 SARS-CoV-2 感染过程中的核心基因。鉴定出 COVID-19 相关的核心基因可以使我们更深入地了解 COVID-19 的分子特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/bddf64af39ac/figure7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/91214a49b697/figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/bc87464880f6/figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/8d52b628989d/figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/b216fb756ddd/figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/1b2de051cdd2/figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/0f69ec5e55a4/figure6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/bddf64af39ac/figure7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/91214a49b697/figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/bc87464880f6/figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/8d52b628989d/figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/b216fb756ddd/figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/1b2de051cdd2/figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/0f69ec5e55a4/figure6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5f9/7714049/bddf64af39ac/figure7.jpg

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