School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai 600117, Tamilnadu, India.
Infect Disord Drug Targets. 2021;21(5):e270421188440. doi: 10.2174/1871526520999201126203738.
Foot infections, being one of the major complications, account for nearly 15% of people with diabetes, and increase their risk for amputation in lower extremities. Though various factors contribute to the development of diabetic foot infection, poor glycemic control poses a greater risk paving the way for a number of micro-organisms to colonize the wound. In order to restore the lost granulation tissue at the ulcer site, the prime aim should not only be attaining glycemic control but also must focus on performing culture by clinically differentiating the stage of infection as well as to manage or control the infection by selecting a rational empiric antibiotic regimen, amidst the uncertainty that exists in choosing best antimicrobial therapy in emerging multi-drug resistance worldwide. This review mainly analyzes that although among the existence of various undefined microbiome being prevalent in causing diabetic foot infections, how the current trend of antibiotics in use aids in treating foot infections in diabetes.
足部感染是主要并发症之一，约占糖尿病患者的 15%，并增加了下肢截肢的风险。尽管有许多因素导致糖尿病足感染的发生，但血糖控制不佳会增加感染的风险，为多种微生物在伤口中定植铺平道路。为了恢复溃疡部位丧失的肉芽组织，首要目标不仅是控制血糖，还必须通过临床区分感染阶段进行培养，以及通过选择合理的经验性抗生素方案来管理或控制感染，因为在全球出现多药耐药的情况下，选择最佳的抗菌治疗方案存在不确定性。这篇综述主要分析了虽然在导致糖尿病足感染的各种未定义微生物组中，目前使用的抗生素趋势如何有助于治疗糖尿病足感染。
