2020 年 5 月至 6 月，德国成功控制的早期热点地区成年人中基于血清学和 PCR 的 SARS-CoV-2 感染累积发病率（CoMoLo 研究）。

Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020.

机构信息

Robert Koch Institute, Berlin, Germany.

These authors contributed equally.

出版信息

Euro Surveill. 2020 Nov;25(47). doi: 10.2807/1560-7917.ES.2020.25.47.2001752.

DOI:10.2807/1560-7917.ES.2020.25.47.2001752
PMID:33243353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7693167/
Abstract

Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5-9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4-14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% naïve adults are still at high COVID-19 risk.

摘要

德国库普费尔泽尔（Kupferzell）发生冠状病毒病（COVID-19）疫情 3 个月后，一项基于人群的研究（n=2203）未发现 RT-PCR 阳性。IgG-ELISA 血清阳性且病毒中和试验阳性的比例为 7.7%（95%置信区间（CI）：6.5-9.1），中和试验阴性的比例为 4.3%。我们估计 12.0%（95%CI：10.4-14.0%）的成年感染者（24.5%无症状），比通报的数字多 6 倍。完全封锁热点地区证实了及时保护措施的有效性。然而，88%的无经验成年人仍面临高 COVID-19 风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9ae/7693167/8d430be9d711/2001752-f1.jpg

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