冠状病毒与胃肠道症状：新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的旧有联系
Coronaviruses and gastrointestinal symptoms: an old liaison for the new SARS-CoV-2.
作者信息
Caio Giacomo, Lungaro Lisa, Cultrera Rosario, De Giorgio Roberto, Volta Umberto
机构信息
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara Italy.
Mucosal Immunology and Biology Research Center, Massachusetts General Hospital - Harvard Medical School, Boston, MA, USA.
出版信息
Gastroenterol Hepatol Bed Bench. 2020 Fall;13(4):341-350.
The coronavirus disease (Covid-19) has caused a pandemic with more than 600,000 deaths to date. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the beta-coronavirus genus that also includes SARS and the Middle East Respiratory Syndrome Coronavirus (MERS). While the typical presentation is given by respiratory symptoms and fever, some patients also report gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain. Several studies have identified the SARS-CoV-2 RNA in stool specimens of infected patients, and its viral receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed in enterocytes. In this short review, we report the frequency of gastrointestinal symptoms in infected patients and suggest possible implications for disease management, transmission, and infection control.
截至目前，冠状病毒病（Covid-19）已导致一场大流行，造成超过60万人死亡。它由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，SARS-CoV-2属于β冠状病毒属，该属还包括SARS和中东呼吸综合征冠状病毒（MERS）。虽然典型症状表现为呼吸道症状和发热，但一些患者也报告有胃肠道症状，如腹泻、恶心、呕吐和腹痛。多项研究已在感染患者的粪便样本中检测到SARS-CoV-2 RNA，并且其病毒受体血管紧张素转换酶2（ACE2）在肠上皮细胞中高度表达。在这篇简短综述中，我们报告了感染患者胃肠道症状的发生率，并提出了对疾病管理、传播和感染控制的可能影响。
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