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一名肝移植受者的新型冠状病毒肺炎表现。

Presentation of COVID-19 in a liver transplant recipient.

作者信息

Hatami Behzad, Ketabi Moghadam Pardis, Zali Mohammadreza

机构信息

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Gastroenterol Hepatol Bed Bench. 2020 Fall;13(4):396-399.

PMID:33244384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7682974/
Abstract

Diarrhea is common after liver transplant. Although the majority of episodes are experienced during the first year of transplantation, they can occur any time after the procedure. Diarrhea can impose a major risk of morbidity and mortality on transplanted patients; so a careful evaluation is required to manage it. There are few studies highlighting the gastrointestinal manifestations of COVID-19, in particular among immunosuppressed patients. The predominant respiratory symptoms of coronavirus cause GI aspects of the virus to be overlooked. This study represents a young woman with a history of liver transplant who was referred to the hospital because of diarrhea, fever, and abdominal pain attributed to coronavirus infection.

摘要

肝移植后腹泻很常见。虽然大多数腹泻发作发生在移植后的第一年,但术后任何时候都可能出现。腹泻会给移植患者带来重大的发病和死亡风险;因此需要进行仔细评估以进行处理。很少有研究强调新型冠状病毒肺炎(COVID-19)的胃肠道表现,尤其是在免疫抑制患者中。冠状病毒主要的呼吸道症状导致该病毒的胃肠道方面被忽视。本研究报告了一名有肝移植史的年轻女性,因腹泻、发热和腹痛被转诊至医院,这些症状归因于冠状病毒感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e938/7682974/b19b6621d054/GHFBB-13-396-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e938/7682974/b19b6621d054/GHFBB-13-396-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e938/7682974/b19b6621d054/GHFBB-13-396-g001.jpg

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Liver transplantation during global COVID-19 pandemic.全球新冠疫情期间的肝移植

本文引用的文献

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Am J Gastroenterol. 2020 May;115(5):766-773. doi: 10.14309/ajg.0000000000000620.
2
Immunosuppression drug-related and clinical manifestation of Coronavirus disease 2019: A therapeutical hypothesis.2019冠状病毒病的免疫抑制药物相关性及临床表现:一种治疗假说
Am J Transplant. 2020 Jul;20(7):1947-1948. doi: 10.1111/ajt.15905. Epub 2020 Apr 15.
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Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission.
World J Clin Cases. 2021 Aug 16;9(23):6608-6623. doi: 10.12998/wjcc.v9.i23.6608.
综述文章:COVID-19 的胃肠道特征和粪便传播的可能性。
Aliment Pharmacol Ther. 2020 May;51(9):843-851. doi: 10.1111/apt.15731. Epub 2020 Mar 31.
4
Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms.74 例伴有胃肠道症状的 2019 年冠状病毒病(COVID-19)患者的流行病学、临床和病毒学特征。
Gut. 2020 Jun;69(6):1002-1009. doi: 10.1136/gutjnl-2020-320926. Epub 2020 Mar 24.
5
Diarrhea in liver transplant recipients: etiology and management.肝移植受者的腹泻:病因与管理
Liver Transpl. 2005 Aug;11(8):881-90. doi: 10.1002/lt.20500.
6
Elevated tacrolimus levels during diarrhea in children after liver transplantation.儿童肝移植术后腹泻期间他克莫司水平升高。
Transplant Proc. 2003 Sep;35(6):2292-4. doi: 10.1016/j.transproceed.2003.08.004.
7
Risk of colorectal adenoma in liver transplant recipients compared to immunocompetent control population undergoing routine screening colonoscopy.与接受常规筛查结肠镜检查的免疫功能正常对照人群相比,肝移植受者患结直肠腺瘤的风险。
J Clin Gastroenterol. 2003 Jul;37(1):72-3. doi: 10.1097/00004836-200307000-00018.
8
Erosive enterocolitis in mycophenolate mofetil-treated renal-transplant recipients with persistent afebrile diarrhea.接受霉酚酸酯治疗的肾移植受者出现持续性无热腹泻并发糜烂性小肠结肠炎。
Transplantation. 2003 Mar 15;75(5):665-72. doi: 10.1097/01.TP.0000053753.43268.F0.
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