钯催化的[60]富勒烯多米诺螺环化反应：多种[60]富勒烯稠合螺[4,5]/[5,5]衍生物的合成
Palladium-catalyzed domino spirocyclization of [60]fullerene: synthesis of diverse [60]fullerene-fused spiro[4,5]/[5,5] derivatives.
作者信息
Ma Jinliang, Liu Tong-Xin, Zhang Pengling, Zhang Chuanjie, Zhang Guisheng
机构信息
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
出版信息
Chem Commun (Camb). 2021 Jan 5;57(1):49-52. doi: 10.1039/d0cc07143a.
Herein a new, general and practical method for the spirocyclization of [60]fullerene through a palladium-catalyzed domino Heck/C-H activation reaction is presented. A wide range of novel [60]fullerene-fused spirocyclic derivatives can be easily and flexibly synthesized with a broad substrate scope and excellent functional-group tolerance. A plausible mechanism involving an alkyl Pd(ii) species as a key intermediate has been proposed.
本文介绍了一种通过钯催化的多米诺Heck/C-H活化反应实现[60]富勒烯螺环化的新的、通用且实用的方法。可以轻松灵活地合成多种新型的[60]富勒烯稠合螺环衍生物，底物范围广且对官能团耐受性良好。已提出一种涉及烷基钯（II）物种作为关键中间体的合理机理。
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