Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, 412 96, Göteborg, Sweden.
Department of Industrial and Materials science, Chalmers University of Technology, 412 96, Göteborg, Sweden.
Chemphyschem. 2021 Feb 3;22(3):250-263. doi: 10.1002/cphc.202000769. Epub 2020 Dec 30.
Biomedical application of graphene derivatives have been intensively studied in last decade. With the exceptional structural, thermal, electrical, and mechanical properties, these materials have attracted immense attention of biomedical scientists to utilize graphene derivatives in biomedical devices to improve their performance or to achieve desired functions. Surfaces of graphene derivatives including graphite, graphene, graphene oxide and reduce graphene oxide have been demonstrated to pave an excellent platform for antimicrobial behavior, enhanced biocompatibility, tissue engineering, biosensors and drug delivery. This review focuses on the recent advancement in the research of biomedical devices with the coatings or highly structured polymer nanocomposite surfaces of graphene derivatives for antimicrobial activity and sterile surfaces comprising an entirely new class of antibacterial materials. Overall, we aim to highlight on the potential of these materials, current understanding and knowledge gap in the antimicrobial behavior and biocompatibility to be utilized of their coatings to prevent the cross infections.
在过去的十年中,石墨烯衍生物在生物医学中的应用得到了广泛的研究。由于其独特的结构、热学、电学和力学性能,这些材料引起了生物医学科学家的极大关注,他们希望将石墨烯衍生物应用于生物医学设备中,以提高其性能或实现预期的功能。石墨烯衍生物的表面,包括石墨、石墨烯、氧化石墨烯和还原氧化石墨烯,已被证明为抗菌行为、增强生物相容性、组织工程、生物传感器和药物输送提供了极好的平台。本综述重点介绍了具有石墨烯衍生物涂层或高度结构化聚合物纳米复合材料表面的生物医学设备的最新研究进展,这些表面具有抗菌活性和无菌表面,包含了一类全新的抗菌材料。总的来说,我们旨在强调这些材料的潜力、目前对其抗菌行为和生物相容性的理解和知识差距,以及将其涂层用于防止交叉感染的可能性。